Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar Rats
Background and Aim: Valsartan as a receptor antagonist angiotensin-II (AngII) is used to treat blood pressure disorders and affects various tissues of the body. Thus,the present study was performed to investigate the effect of Valsartan on the axis of the pituitary-gonadal axis in mature female rats...
| Main Authors: | , |
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| Format: | Article |
| Language: | fas |
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Birjand University of Medical Sciences and Health Services
2013-02-01
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| Series: | مجله دانشگاه علوم پزشکی بیرجند |
| Subjects: | |
| Online Access: | http://journal.bums.ac.ir/browse.php?a_code=A-10-646-2&slc_lang=en&sid=1 |
| _version_ | 1811232970336370688 |
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| author | Ebrahim Hosseini Mozhde Hjeidari |
| author_facet | Ebrahim Hosseini Mozhde Hjeidari |
| author_sort | Ebrahim Hosseini |
| collection | DOAJ |
| description | Background and Aim: Valsartan as a receptor antagonist angiotensin-II (AngII) is used to treat blood pressure disorders and affects various tissues of the body. Thus,the present study was performed to investigate the effect of Valsartan on the axis of the pituitary-gonadal axis in mature female rats.
Materials and Methods: In this research, 40 mature female Wistar rats were randomly divided into 8 member groups including control, sham and experimental groups. Initially, all the animals were homogenized through intramuscular injection of estradiol valerate and progesterone. Then the animals of sham group daily received 1 ml of olive oil (solvent) and the experimental groups were gavaged daily doses of 100, 200 and 400 mg/ Kg Wt , of Valsartan The control group members were not Administered anything. All drugs were administered for 21 days and at the end of the period, through deriving blood from the heart of animals the required serum was prepared by means of relevant hormonal kits to measure the levels of FSH, LH, estrogen and progesterone. The obtained data was evaluated using ANOVA and Tukey tests ,and P< 0/05 was taken as the significant level.
Results: Statistical results analysis showed that Valsartan caused a significant reduction in hormones of FSH, LH, estrogen and progesterone.
Conclusion: Valsartan , as a receptor antagonist of Ang II inhibits the secretion of gonadotropin hormones and accelerates their effect on blocking the follicular cells of the female sex ,causing the reduction of female hormones. |
| first_indexed | 2024-04-12T11:13:18Z |
| format | Article |
| id | doaj.art-44088263c48942948aeeb0039c074710 |
| institution | Directory Open Access Journal |
| issn | 1607-2197 2423-6152 |
| language | fas |
| last_indexed | 2024-04-12T11:13:18Z |
| publishDate | 2013-02-01 |
| publisher | Birjand University of Medical Sciences and Health Services |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی بیرجند |
| spelling | doaj.art-44088263c48942948aeeb0039c0747102022-12-22T03:35:34ZfasBirjand University of Medical Sciences and Health Servicesمجله دانشگاه علوم پزشکی بیرجند1607-21972423-61522013-02-01194409415Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar RatsEbrahim Hosseini0Mozhde Hjeidari1 Department of Biology, Science and Research Branch, Islamic Azad University, Fars, Iran Department of Biology, University of Pardis, Shiraz, Iran Background and Aim: Valsartan as a receptor antagonist angiotensin-II (AngII) is used to treat blood pressure disorders and affects various tissues of the body. Thus,the present study was performed to investigate the effect of Valsartan on the axis of the pituitary-gonadal axis in mature female rats. Materials and Methods: In this research, 40 mature female Wistar rats were randomly divided into 8 member groups including control, sham and experimental groups. Initially, all the animals were homogenized through intramuscular injection of estradiol valerate and progesterone. Then the animals of sham group daily received 1 ml of olive oil (solvent) and the experimental groups were gavaged daily doses of 100, 200 and 400 mg/ Kg Wt , of Valsartan The control group members were not Administered anything. All drugs were administered for 21 days and at the end of the period, through deriving blood from the heart of animals the required serum was prepared by means of relevant hormonal kits to measure the levels of FSH, LH, estrogen and progesterone. The obtained data was evaluated using ANOVA and Tukey tests ,and P< 0/05 was taken as the significant level. Results: Statistical results analysis showed that Valsartan caused a significant reduction in hormones of FSH, LH, estrogen and progesterone. Conclusion: Valsartan , as a receptor antagonist of Ang II inhibits the secretion of gonadotropin hormones and accelerates their effect on blocking the follicular cells of the female sex ,causing the reduction of female hormones.http://journal.bums.ac.ir/browse.php?a_code=A-10-646-2&slc_lang=en&sid=1Valsartan estrogen progesterone FSH LH Rat |
| spellingShingle | Ebrahim Hosseini Mozhde Hjeidari Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar Rats مجله دانشگاه علوم پزشکی بیرجند Valsartan estrogen progesterone FSH LH Rat |
| title | Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar Rats |
| title_full | Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar Rats |
| title_fullStr | Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar Rats |
| title_full_unstemmed | Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar Rats |
| title_short | Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar Rats |
| title_sort | effect of valsartan on the hormones of pituitary gonadal axis performance in mature female wistar rats |
| topic | Valsartan estrogen progesterone FSH LH Rat |
| url | http://journal.bums.ac.ir/browse.php?a_code=A-10-646-2&slc_lang=en&sid=1 |
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