Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis
Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with neurotoxic, inflammatory and nutritional status . The pulpose of this study is to investigate the changes in plasma BDNF concentration that were induced by chronic uremic condition. Using an enzyme-linked immu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Nephrology
2012-06-01
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| Series: | Kidney Research and Clinical Practice |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913212005803 |
| _version_ | 1818515548412051456 |
|---|---|
| author | Seok Joon Shin Sungjin Chung Hyung Wook Kim Ho Cheol |
| author_facet | Seok Joon Shin Sungjin Chung Hyung Wook Kim Ho Cheol |
| author_sort | Seok Joon Shin |
| collection | DOAJ |
| description | Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with neurotoxic, inflammatory and nutritional status . The pulpose of this study is to investigate the changes in plasma BDNF concentration that were induced by chronic uremic condition. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in pre-hemodialysis (pre-HD), peritoneal dialysis (PD) patients and in a control group. The plasma BDNF concentrations of pre-HD, PD patients were significantly higher compared with those of controls (856.3 ± 879.1, 1167.9 ± 647.5 versus 403.1 ± 288.9 pg/ml, respectively). The plasma BDNF in dialysis patients was positively correlated with high-sensitivity C reactive protein (hs-CRP) and with serum albumin negatively.
Plasma BDNF
hs-CRP
Albumin
r
p
r
p
Pre-HD
0.321
0.025
-0.298
0.021
PD
0.414
0.070
-0.527
0.008
Pre-HD + PD
0.446
0.001
-0.453
0.001
In conclusion, BDNF might plays some role in the neurotoxicity of uremia and associated with inflammation and malnutrition in dialysis patients. |
| first_indexed | 2024-12-11T00:30:19Z |
| format | Article |
| id | doaj.art-440b6e4a0eec483da9d09c8b84365d56 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-11T00:30:19Z |
| publishDate | 2012-06-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-440b6e4a0eec483da9d09c8b84365d562022-12-22T01:27:21ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322012-06-01312A7310.1016/j.krcp.2012.04.547Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal DialysisSeok Joon ShinSungjin ChungHyung Wook KimHo CheolRecent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with neurotoxic, inflammatory and nutritional status . The pulpose of this study is to investigate the changes in plasma BDNF concentration that were induced by chronic uremic condition. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in pre-hemodialysis (pre-HD), peritoneal dialysis (PD) patients and in a control group. The plasma BDNF concentrations of pre-HD, PD patients were significantly higher compared with those of controls (856.3 ± 879.1, 1167.9 ± 647.5 versus 403.1 ± 288.9 pg/ml, respectively). The plasma BDNF in dialysis patients was positively correlated with high-sensitivity C reactive protein (hs-CRP) and with serum albumin negatively. Plasma BDNF hs-CRP Albumin r p r p Pre-HD 0.321 0.025 -0.298 0.021 PD 0.414 0.070 -0.527 0.008 Pre-HD + PD 0.446 0.001 -0.453 0.001 In conclusion, BDNF might plays some role in the neurotoxicity of uremia and associated with inflammation and malnutrition in dialysis patients.http://www.sciencedirect.com/science/article/pii/S2211913212005803 |
| spellingShingle | Seok Joon Shin Sungjin Chung Hyung Wook Kim Ho Cheol Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis Kidney Research and Clinical Practice |
| title | Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis |
| title_full | Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis |
| title_fullStr | Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis |
| title_full_unstemmed | Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis |
| title_short | Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis |
| title_sort | plasma brain derived neurotrophic factor levels of patients undergoing hemodialysis and peritoneal dialysis |
| url | http://www.sciencedirect.com/science/article/pii/S2211913212005803 |
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