Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy
Abstract Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC than any other solid tumor. This stems from a current standard of care management ap...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-019-1277-1 |
| _version_ | 1818441855012962304 |
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| author | William A. Hall Karyn A. Goodman |
| author_facet | William A. Hall Karyn A. Goodman |
| author_sort | William A. Hall |
| collection | DOAJ |
| description | Abstract Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC than any other solid tumor. This stems from a current standard of care management approach that needs to be inspired and transformed with modern treatment techniques and novel therapeutic options. Radiation therapy has historically been a central component in the treatment of pancreatic adenocarcinoma; however, the role of radiation therapy has been called into question based on the publication of clinical trials with conflicting results. We present an overview of the rationale for radiation therapy in resectable, borderline resectable, and unresectable pancreatic adenocarcinoma. We further present a summary of emerging clinical data and future directions to improve outcomes in this devastating malignancy. |
| first_indexed | 2024-12-14T18:34:52Z |
| format | Article |
| id | doaj.art-440ba1c8a9b0427686b044bdd585d6d6 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-14T18:34:52Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-440ba1c8a9b0427686b044bdd585d6d62022-12-21T22:51:39ZengBMCRadiation Oncology1748-717X2019-06-011411510.1186/s13014-019-1277-1Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancyWilliam A. Hall0Karyn A. Goodman1Department of Radiation Oncology, Medical College of WisconsinDepartment of Radiation Oncology, University of ColoradoAbstract Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC than any other solid tumor. This stems from a current standard of care management approach that needs to be inspired and transformed with modern treatment techniques and novel therapeutic options. Radiation therapy has historically been a central component in the treatment of pancreatic adenocarcinoma; however, the role of radiation therapy has been called into question based on the publication of clinical trials with conflicting results. We present an overview of the rationale for radiation therapy in resectable, borderline resectable, and unresectable pancreatic adenocarcinoma. We further present a summary of emerging clinical data and future directions to improve outcomes in this devastating malignancy.http://link.springer.com/article/10.1186/s13014-019-1277-1Pancreatic cancerPancreatic adenocarcinomaPancreatic radiation therapyPancreatic SBRTPRODIGE trialPREOPANC-1 trial |
| spellingShingle | William A. Hall Karyn A. Goodman Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy Radiation Oncology Pancreatic cancer Pancreatic adenocarcinoma Pancreatic radiation therapy Pancreatic SBRT PRODIGE trial PREOPANC-1 trial |
| title | Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy |
| title_full | Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy |
| title_fullStr | Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy |
| title_full_unstemmed | Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy |
| title_short | Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy |
| title_sort | radiation therapy for pancreatic adenocarcinoma a treatment option that must be considered in the management of a devastating malignancy |
| topic | Pancreatic cancer Pancreatic adenocarcinoma Pancreatic radiation therapy Pancreatic SBRT PRODIGE trial PREOPANC-1 trial |
| url | http://link.springer.com/article/10.1186/s13014-019-1277-1 |
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