IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma
Background: The aim of this study was to (i) determine IMP3 protein expression in benign and malignant laryngeal lesions, (ii) compare its expression to Ki-67, p53, cyclin D1, and (iii) finally, to examine the prognostic power of IMP3 in squamous cell carcinomas of the larynx (LSSC). Methods: IMP3 p...
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MDPI AG
2021-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/17/4306 |
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| author | Diana Maržić Blažen Marijić Tamara Braut Stefan Janik Manuela Avirović Ita Hadžisejdić Filip Tudor Katarina Radobuljac Miran Čoklo Boban M. Erovic |
| author_facet | Diana Maržić Blažen Marijić Tamara Braut Stefan Janik Manuela Avirović Ita Hadžisejdić Filip Tudor Katarina Radobuljac Miran Čoklo Boban M. Erovic |
| author_sort | Diana Maržić |
| collection | DOAJ |
| description | Background: The aim of this study was to (i) determine IMP3 protein expression in benign and malignant laryngeal lesions, (ii) compare its expression to Ki-67, p53, cyclin D1, and (iii) finally, to examine the prognostic power of IMP3 in squamous cell carcinomas of the larynx (LSSC). Methods: IMP3 protein expression was evaluated in 145 patients, including 62 LSCC, 45 dysplasia (25 with low and 20 with high-grade dysplasia), and 38 benign lesions (vocal cord polyps and nodules). Results: IMP3 was significantly higher expressed in LSCC compared to dysplasia and benign lesions (<i>p</i> < 0.001; <i>p</i> < 0.001, respectively). Similarly, higher expression patterns were observed for Ki-67 and p53, whereas cyclin D1 was equally distributed in all three lesions. IMP3 (<i>p</i> = 0.04) and Ki-67 (<i>p</i> = 0.02) expressions were significantly linked to neck node positivity, and IMP3 overexpression to worse disease-specific survival (<i>p</i> = 0.027). Conclusion: Since IMP3 showed significantly higher expression in laryngeal carcinomas, but not in high- or low-grade dysplasia, it serves as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression represented a significantly worse prognosticator for clinical outcomes of patients with squamous cell carcinoma of the larynx. |
| first_indexed | 2024-03-10T08:14:26Z |
| format | Article |
| id | doaj.art-440baa927e104c4c807c61590bcee279 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T08:14:26Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-440baa927e104c4c807c61590bcee2792023-11-22T10:25:22ZengMDPI AGCancers2072-66942021-08-011317430610.3390/cancers13174306IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell CarcinomaDiana Maržić0Blažen Marijić1Tamara Braut2Stefan Janik3Manuela Avirović4Ita Hadžisejdić5Filip Tudor6Katarina Radobuljac7Miran Čoklo8Boban M. Erovic9Department of Audiology and Phoniatrics, Clinical Hospital Center Rijeka, 51000 Rijeka, CroatiaFaculty of Medicine, University of Rijeka, 51000 Rijeka, CroatiaFaculty of Medicine, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, 1190 Vienna, AustriaFaculty of Medicine, University of Rijeka, 51000 Rijeka, CroatiaFaculty of Medicine, University of Rijeka, 51000 Rijeka, CroatiaFaculty of Medicine, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Audiology and Phoniatrics, Clinical Hospital Center Rijeka, 51000 Rijeka, CroatiaCenter for Applied Bioanthropology, Institute for Anthropological Research, 10000 Zagreb, CroatiaInstitute of Head and Neck Diseases, Evangelical Hospital, 1180 Vienna, AustriaBackground: The aim of this study was to (i) determine IMP3 protein expression in benign and malignant laryngeal lesions, (ii) compare its expression to Ki-67, p53, cyclin D1, and (iii) finally, to examine the prognostic power of IMP3 in squamous cell carcinomas of the larynx (LSSC). Methods: IMP3 protein expression was evaluated in 145 patients, including 62 LSCC, 45 dysplasia (25 with low and 20 with high-grade dysplasia), and 38 benign lesions (vocal cord polyps and nodules). Results: IMP3 was significantly higher expressed in LSCC compared to dysplasia and benign lesions (<i>p</i> < 0.001; <i>p</i> < 0.001, respectively). Similarly, higher expression patterns were observed for Ki-67 and p53, whereas cyclin D1 was equally distributed in all three lesions. IMP3 (<i>p</i> = 0.04) and Ki-67 (<i>p</i> = 0.02) expressions were significantly linked to neck node positivity, and IMP3 overexpression to worse disease-specific survival (<i>p</i> = 0.027). Conclusion: Since IMP3 showed significantly higher expression in laryngeal carcinomas, but not in high- or low-grade dysplasia, it serves as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression represented a significantly worse prognosticator for clinical outcomes of patients with squamous cell carcinoma of the larynx.https://www.mdpi.com/2072-6694/13/17/4306IMP3laryngeal carcinomadysplasiaimmunohistochemistrysurvival |
| spellingShingle | Diana Maržić Blažen Marijić Tamara Braut Stefan Janik Manuela Avirović Ita Hadžisejdić Filip Tudor Katarina Radobuljac Miran Čoklo Boban M. Erovic IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma Cancers IMP3 laryngeal carcinoma dysplasia immunohistochemistry survival |
| title | IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma |
| title_full | IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma |
| title_fullStr | IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma |
| title_full_unstemmed | IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma |
| title_short | IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma |
| title_sort | imp3 protein overexpression is linked to unfavorable outcome in laryngeal squamous cell carcinoma |
| topic | IMP3 laryngeal carcinoma dysplasia immunohistochemistry survival |
| url | https://www.mdpi.com/2072-6694/13/17/4306 |
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