The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis.

The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis.

Cyclophilins are a group of highly conserved cytosolic enzymes that have a peptidylprolyl cis/trans isomerase activity. Cyclophilin A (CyPA) can be secreted in the extracellular space by inflammatory cells and upon cell death. The presence of CyPA in patients with non-ischemic cardiomyopathy is asso...

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Bibliographic Details
Main Authors: David Heinzmann, Anna Bangert, Anna-Maria Müller, Saskia N I von Ungern-Sternberg, Frederic Emschermann, Tanja Schönberger, Madhumita Chatterjee, Andreas F Mack, Karin Klingel, Reinhard Kandolf, Miroslav Malesevic, Oliver Borst, Meinrad Gawaz, Harald F Langer, Hugo Katus, Gunter Fischer, Andreas E May, Ziya Kaya, Peter Seizer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4404136?pdf=render

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