Unchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic Season
We conducted a nationwide hospital-based prospective study in Germany of influenza A(H1N1)pdm09 cases among children <15 years of age admitted to pediatric intensive care units and related deaths during the 2009–10 pandemic and the 2010–11 postpandemic influenza seasons. We identified 156 eligibl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2012-11-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/18/11/12-0719_article |
| _version_ | 1818671263469535232 |
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| author | Mathias Altmann Lena Fiebig Silke Buda Rüdiger von Kries Manuel Dehnert Walter Haas |
| author_facet | Mathias Altmann Lena Fiebig Silke Buda Rüdiger von Kries Manuel Dehnert Walter Haas |
| author_sort | Mathias Altmann |
| collection | DOAJ |
| description | We conducted a nationwide hospital-based prospective study in Germany of influenza A(H1N1)pdm09 cases among children <15 years of age admitted to pediatric intensive care units and related deaths during the 2009–10 pandemic and the 2010–11 postpandemic influenza seasons. We identified 156 eligible patients: 112 in 2009–10 and 44 in 2010–11. Although a shift to younger patients occurred in 2010–11 (median age 3.2 vs. 5.3 years), infants <1 year of age remained the most affected. Underlying immunosuppression was a risk factor for hospital-acquired infections (p = 0.013), which accounted for 14% of cases. Myocarditis was predictive of death (p = 0.006). Of the 156 case-patients, 17% died; the difference between seasons was not significant (p = 0.473). Our findings stress the challenge of preventing severe postpandemic influenza infection in children and the need to prevent nosocomial transmission of influenza virus, especially in immunosuppressed children. |
| first_indexed | 2024-12-17T07:21:13Z |
| format | Article |
| id | doaj.art-440d77d6951e4babb63979f750605f86 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-17T07:21:13Z |
| publishDate | 2012-11-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-440d77d6951e4babb63979f750605f862022-12-21T21:58:46ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592012-11-0118111755176210.3201/eid1811.120719Unchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic SeasonMathias AltmannLena FiebigSilke BudaRüdiger von KriesManuel DehnertWalter HaasWe conducted a nationwide hospital-based prospective study in Germany of influenza A(H1N1)pdm09 cases among children <15 years of age admitted to pediatric intensive care units and related deaths during the 2009–10 pandemic and the 2010–11 postpandemic influenza seasons. We identified 156 eligible patients: 112 in 2009–10 and 44 in 2010–11. Although a shift to younger patients occurred in 2010–11 (median age 3.2 vs. 5.3 years), infants <1 year of age remained the most affected. Underlying immunosuppression was a risk factor for hospital-acquired infections (p = 0.013), which accounted for 14% of cases. Myocarditis was predictive of death (p = 0.006). Of the 156 case-patients, 17% died; the difference between seasons was not significant (p = 0.473). Our findings stress the challenge of preventing severe postpandemic influenza infection in children and the need to prevent nosocomial transmission of influenza virus, especially in immunosuppressed children.https://wwwnc.cdc.gov/eid/article/18/11/12-0719_articleinfluenza A(H1N1)pdm09 virusinfluenzachildrencritically illpostpandemichospital-acquired infection |
| spellingShingle | Mathias Altmann Lena Fiebig Silke Buda Rüdiger von Kries Manuel Dehnert Walter Haas Unchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic Season Emerging Infectious Diseases influenza A(H1N1)pdm09 virus influenza children critically ill postpandemic hospital-acquired infection |
| title | Unchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic Season |
| title_full | Unchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic Season |
| title_fullStr | Unchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic Season |
| title_full_unstemmed | Unchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic Season |
| title_short | Unchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic Season |
| title_sort | unchanged severity of influenza a h1n1 pdm09 infection in children during first postpandemic season |
| topic | influenza A(H1N1)pdm09 virus influenza children critically ill postpandemic hospital-acquired infection |
| url | https://wwwnc.cdc.gov/eid/article/18/11/12-0719_article |
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