Relationship Between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients
Exposure to chronic low levels of aflatoxin B1 (AFB1) contamination can lead to immune suppression and nutritional consequences that might greatly contributed in the increase of hepatocellular carcinoma (HCC). The toxicity of AFB1 is greatly vary between different population, affected by age, gen...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2018-09-01
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| Series: | Journal of Pure and Applied Microbiology |
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| Online Access: | https://microbiologyjournal.org/relationship-between-aflatoxin-b1-exposure-and-etiology-of-liver-disease-in-saudi-arabian-patients-2/ |
| _version_ | 1819025500505374720 |
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| author | Randa Mohamed M.A. Farag Dujana AlAyobi Hye-Joo Kwon Afaf EL-Ansary |
| author_facet | Randa Mohamed M.A. Farag Dujana AlAyobi Hye-Joo Kwon Afaf EL-Ansary |
| author_sort | Randa Mohamed M.A. Farag |
| collection | DOAJ |
| description | Exposure to chronic low levels of aflatoxin B1 (AFB1) contamination can lead to
immune suppression and nutritional consequences that might greatly contributed in the
increase of hepatocellular carcinoma (HCC). The toxicity of AFB1 is greatly vary between
different population, affected by age, gender, and environmental factors. Aflatoxin B1 (AFB1)
was measured in 50 blood samples collected from non B, C hepatitis viruses and non CMV-Ab
liver disease patients from different general hospitals and polyclinic in KSA during period 01-
2013 to 06-2014. All Patients demonstrate elevation of ALT and AST with unknown etiology.
Serum samples were obtained and kept at “20 °C for AFB1detection. Out of the 50 blood samples,
38 demonstrate a detectable serum level of AFB1 while the remaining 12 patients were AFB1
negative. ALT was significantly higher in AFB1 positive samples compared to control AFB1-
negative. AFB1 was positively correlated with AST and ALT as liver function enzymes and
with age as a risk factor of long duration of AFB1 chronic exposure. Multiple linear regression
analysis ascertained the association between AFB1 chronic exposure and ALT increase in
liver dysfunction Saudi patients. Measurement of elevated ALT as marker of liver injury in
AFB1 chronically exposed Saudi patients can help to avoid the future development of HCC.
Moreover, early detection of AFB1 exposure, together with early vaccination against HBV and
HCV can remove the synergistic effects of these two etiological factors and thus decrease the
risk of developing liver cancer. |
| first_indexed | 2024-12-21T05:11:40Z |
| format | Article |
| id | doaj.art-440f1c2642984e52a7dfa30acf3acc4c |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-12-21T05:11:40Z |
| publishDate | 2018-09-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-440f1c2642984e52a7dfa30acf3acc4c2022-12-21T19:15:02ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2018-09-011231147115310.22207/JPAM.12.3.13Relationship Between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian PatientsRanda Mohamed M.A. Farag0Dujana AlAyobi1Hye-Joo Kwon2Afaf EL-Ansary3Assistant Prof of Virology and molecular microbiology, Health Science Research Central, Princess Nourah bint Abdulrahman University (PNU), Kingdom of Saudi Arabia (KSA). Prof of Genetic, Biology department, Princess Nourah bint Abdulrahman University (PNU), Kingdom Saudi Arabia (KSA).Assistant Prof of Molecular Biology, Biology department, Princess Nourah bint Abdulrahman University (PNU), Kingdom of Saudi Arabia (KSA).Prof Biochemistry, Central Labe, King Saud University (KSU).Exposure to chronic low levels of aflatoxin B1 (AFB1) contamination can lead to immune suppression and nutritional consequences that might greatly contributed in the increase of hepatocellular carcinoma (HCC). The toxicity of AFB1 is greatly vary between different population, affected by age, gender, and environmental factors. Aflatoxin B1 (AFB1) was measured in 50 blood samples collected from non B, C hepatitis viruses and non CMV-Ab liver disease patients from different general hospitals and polyclinic in KSA during period 01- 2013 to 06-2014. All Patients demonstrate elevation of ALT and AST with unknown etiology. Serum samples were obtained and kept at “20 °C for AFB1detection. Out of the 50 blood samples, 38 demonstrate a detectable serum level of AFB1 while the remaining 12 patients were AFB1 negative. ALT was significantly higher in AFB1 positive samples compared to control AFB1- negative. AFB1 was positively correlated with AST and ALT as liver function enzymes and with age as a risk factor of long duration of AFB1 chronic exposure. Multiple linear regression analysis ascertained the association between AFB1 chronic exposure and ALT increase in liver dysfunction Saudi patients. Measurement of elevated ALT as marker of liver injury in AFB1 chronically exposed Saudi patients can help to avoid the future development of HCC. Moreover, early detection of AFB1 exposure, together with early vaccination against HBV and HCV can remove the synergistic effects of these two etiological factors and thus decrease the risk of developing liver cancer.https://microbiologyjournal.org/relationship-between-aflatoxin-b1-exposure-and-etiology-of-liver-disease-in-saudi-arabian-patients-2/aflatoxin b1transaminaseshepatocellular carcinomasaudi patientsliver dysfunction |
| spellingShingle | Randa Mohamed M.A. Farag Dujana AlAyobi Hye-Joo Kwon Afaf EL-Ansary Relationship Between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients Journal of Pure and Applied Microbiology aflatoxin b1 transaminases hepatocellular carcinoma saudi patients liver dysfunction |
| title | Relationship Between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients |
| title_full | Relationship Between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients |
| title_fullStr | Relationship Between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients |
| title_full_unstemmed | Relationship Between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients |
| title_short | Relationship Between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients |
| title_sort | relationship between aflatoxin b1 exposure and etiology of liver disease in saudi arabian patients |
| topic | aflatoxin b1 transaminases hepatocellular carcinoma saudi patients liver dysfunction |
| url | https://microbiologyjournal.org/relationship-between-aflatoxin-b1-exposure-and-etiology-of-liver-disease-in-saudi-arabian-patients-2/ |
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