Chemokines and Innate Lymphoid Cells in Skin Inflammation
As the outermost barrier, skin plays an important role in protecting our bodies against outside invasion. Under stable conditions or during inflammation, leukocytes migration is essential for restoring homeostasis in the skin. Immune cells trafficking is orchestrated by chemokines; leukocytes expres...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/11/3074 |
| _version_ | 1827677008186834944 |
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| author | Zhengwang Sun Ravi Vattepu Songfa Zhang |
| author_facet | Zhengwang Sun Ravi Vattepu Songfa Zhang |
| author_sort | Zhengwang Sun |
| collection | DOAJ |
| description | As the outermost barrier, skin plays an important role in protecting our bodies against outside invasion. Under stable conditions or during inflammation, leukocytes migration is essential for restoring homeostasis in the skin. Immune cells trafficking is orchestrated by chemokines; leukocytes express receptors that bind to chemokines and trigger migration. The homeostasis of the immune ecosystem is an extremely complicated dynamic process that requires the cooperation of innate and adaptive immune cells. Emerging studies have been shedding a light on the unique characteristics of skin-resident innate lymphoid cells (ILCs). In this review, we discuss how chemokines orchestrate skin ILCs trafficking and contribute to tissue homeostasis and how abnormal chemokine–chemokine receptor interactions contribute to and augment skin inflammation, as seen in conditions such as contact hypersensitivity, atopic dermatitis, and psoriasis. |
| first_indexed | 2024-03-10T05:36:10Z |
| format | Article |
| id | doaj.art-440f7bc1295d4bc3aee03df229d01a0a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:36:10Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-440f7bc1295d4bc3aee03df229d01a0a2023-11-22T22:50:54ZengMDPI AGCells2073-44092021-11-011011307410.3390/cells10113074Chemokines and Innate Lymphoid Cells in Skin InflammationZhengwang Sun0Ravi Vattepu1Songfa Zhang2Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USACenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Gynecological Oncology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, ChinaAs the outermost barrier, skin plays an important role in protecting our bodies against outside invasion. Under stable conditions or during inflammation, leukocytes migration is essential for restoring homeostasis in the skin. Immune cells trafficking is orchestrated by chemokines; leukocytes express receptors that bind to chemokines and trigger migration. The homeostasis of the immune ecosystem is an extremely complicated dynamic process that requires the cooperation of innate and adaptive immune cells. Emerging studies have been shedding a light on the unique characteristics of skin-resident innate lymphoid cells (ILCs). In this review, we discuss how chemokines orchestrate skin ILCs trafficking and contribute to tissue homeostasis and how abnormal chemokine–chemokine receptor interactions contribute to and augment skin inflammation, as seen in conditions such as contact hypersensitivity, atopic dermatitis, and psoriasis.https://www.mdpi.com/2073-4409/10/11/3074chemokinesinnate lymphoid cellsskincontact hypersensitivityatopic dermatitispsoriasis |
| spellingShingle | Zhengwang Sun Ravi Vattepu Songfa Zhang Chemokines and Innate Lymphoid Cells in Skin Inflammation Cells chemokines innate lymphoid cells skin contact hypersensitivity atopic dermatitis psoriasis |
| title | Chemokines and Innate Lymphoid Cells in Skin Inflammation |
| title_full | Chemokines and Innate Lymphoid Cells in Skin Inflammation |
| title_fullStr | Chemokines and Innate Lymphoid Cells in Skin Inflammation |
| title_full_unstemmed | Chemokines and Innate Lymphoid Cells in Skin Inflammation |
| title_short | Chemokines and Innate Lymphoid Cells in Skin Inflammation |
| title_sort | chemokines and innate lymphoid cells in skin inflammation |
| topic | chemokines innate lymphoid cells skin contact hypersensitivity atopic dermatitis psoriasis |
| url | https://www.mdpi.com/2073-4409/10/11/3074 |
| work_keys_str_mv | AT zhengwangsun chemokinesandinnatelymphoidcellsinskininflammation AT ravivattepu chemokinesandinnatelymphoidcellsinskininflammation AT songfazhang chemokinesandinnatelymphoidcellsinskininflammation |