Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure

Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure

Abstract Extracellular amyloid-β (Aβ) plaques and intracellular aggregates of tau protein in form of neurofibrillary tangles (NFT) are pathological hallmarks of Alzheimer’s disease (AD). The exact mechanism how these two protein aggregates interact in AD is still a matter of debate. Neuritic plaques...

Full description

Bibliographic Details
Main Authors: Wangchen Tsering, Gabriela P. Hery, Jennifer L. Phillips, Kiara Lolo, Tim Bathe, Jonathan A. Villareal, Isabelle Y. Ruan, Stefan Prokop
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Acta Neuropathologica Communications
Subjects:
Neuritic plaque
Alzheimer’s disease
Spatial transcriptomics
Dystrophic neurites
Regenerative failure
Online Access:https://doi.org/10.1186/s40478-023-01688-6

Similar Items

Similar Items