Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy

Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy

Summary: Fibrosis is a prominent pathological feature of skeletal muscle in Duchenne muscular dystrophy (DMD). The commonly used disease mouse model, mdx5cv, displays progressive fibrosis in the diaphragm but not limb muscles. We use single-cell RNA sequencing to determine the cellular expression of...

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Bibliographic Details
Main Authors: Xingyu Wang, Jianming Chen, Sachiko T. Homma, Yinhang Wang, Gregory R. Smith, Frederique Ruf-Zamojski, Stuart C. Sealfon, Lan Zhou
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Musculoskeletal medicine
Genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422202048X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422202048X

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