Salivary Visfatin Concentration in Response to Non-surgical Periodontal Therapy
Introduction: Visfatin is a pro-inflammatory cytokine that has been associated with several immunomodulating processes. The relationship between visfatin and periodontitis has been the subject of a few studies that have described visfatin as an inflammatory marker for periodontitis. However, stu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5773/11537_CE(Ra1)_F(PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Visfatin is a pro-inflammatory cytokine that has
been associated with several immunomodulating processes.
The relationship between visfatin and periodontitis has been
the subject of a few studies that have described visfatin as
an inflammatory marker for periodontitis. However, studies on
visfatin as a potential therapeutic target in periodontal diseases
are scarce. In the present study, we evaluated the alterations in
salivary visfatin levels in response to non-surgical periodontal
treatment.
Materials and Methods: Twenty individuals with moderate to
severe chronic periodontitis and twenty periodontally healthy
individuals were selected for this study according to clinical
parameters. Patients with chronic periodontitis were treated
by non-surgical periodontal therapy. Clinical parameters were
recorded and saliva samples were obtained from the control
group and test group before (T1 group) and one month after
periodontal treatment (T2 group). Salivary visfatin concentrations
were measured by standard enzyme-linked immunosorbent
assay (ELISA). Statistical analysis was performed with the
statistical software SPSS, version 18.
Results: Visfatin was detectable in all samples. T1 and control
groups were significantly different in terms of clinical parameters
and visfatin levels. Visfatin concentrations were reduced
significantly after non-surgical periodontal therapy. Periodontal
treatment also resulted in significant reductions of all clinical
parameters with the exception of clinical attachment level.
Conclusion: The results demonstrated that salivary levels of
visfatin are reduced after non-surgical periodontal therapy to
the levels comparable with those found in healthy individuals.
Therefore, the salivary visfatin level may have the potential to
be a target marker for assessment of responses to non-surgical
periodontal therapy. However, more studies with larger sample
sizes are necessary to validate these findings. |
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| ISSN: | 2249-782X 0973-709X |