Pathological Evaluation of Sentinel Lymph Nodes for Breast Cancer
Recently, sentinel lymph node (SLN) biopsy has been employed to avoid unnecessary lymph node dissection, because SLN negativity for carcinoma metastases may imply an extremely low possibility of non-SLN involvement. Pathological evaluation is essential, but standardized procedures have not yet been...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-10-01
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| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958409600476 |
| _version_ | 1818253623780442112 |
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| author | Takuya Moriya Shin Usami Hiroshi Tada Atsuko Kasajima Kazuyuki Ishida Yoshiyuki Kariya Noriaki Ohuchi Hironobu Sasano |
| author_facet | Takuya Moriya Shin Usami Hiroshi Tada Atsuko Kasajima Kazuyuki Ishida Yoshiyuki Kariya Noriaki Ohuchi Hironobu Sasano |
| author_sort | Takuya Moriya |
| collection | DOAJ |
| description | Recently, sentinel lymph node (SLN) biopsy has been employed to avoid unnecessary lymph node dissection, because SLN negativity for carcinoma metastases may imply an extremely low possibility of non-SLN involvement. Pathological evaluation is essential, but standardized procedures have not yet been determined. Intraoperative consultation, either by frozen section (multiple slices are desirable) or touch imprint cytology, are usually very useful. Their accuracy, however, is variable and depends on the procedures used, but specificity is characteristically 100%, and the missed metastatic focus is always quite minute. After fixation, multiple sections, immuno-histochemistry, and their combination will be able to detect small metastatic foci more frequently. The clinical significance of small or submicro- or occult metastases have not yet been clarified, and further investigations are needed. If the SLN is positive for carcinoma metastases, both the procedure for detection and the size of the metastatic focus should be clarified on the pathological reports. |
| first_indexed | 2024-12-12T16:43:01Z |
| format | Article |
| id | doaj.art-44145597adb74c288f0a0027e9dce3ff |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-12T16:43:01Z |
| publishDate | 2004-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-44145597adb74c288f0a0027e9dce3ff2022-12-22T00:18:32ZengElsevierAsian Journal of Surgery1015-95842004-10-0127425626110.1016/S1015-9584(09)60047-6Pathological Evaluation of Sentinel Lymph Nodes for Breast CancerTakuya Moriya0Shin Usami1Hiroshi Tada2Atsuko Kasajima3Kazuyuki Ishida4Yoshiyuki Kariya5Noriaki Ohuchi6Hironobu Sasano7Department of Pathology, Tohoku University Hospital, Sendai, JapanDepartment of Pathology, Tohoku University Hospital, Sendai, JapanDepartment of Surgery, Tohoku University Hospital, Sendai, JapanDepartment of Pathology, Tohoku University Hospital, Sendai, JapanDepartment of Pathology, Tohoku University Hospital, Sendai, JapanDepartment of Pathology, Tohoku University Hospital, Sendai, JapanDepartment of Surgery, Tohoku University Hospital, Sendai, JapanDepartment of Pathology, Tohoku University Hospital, Sendai, JapanRecently, sentinel lymph node (SLN) biopsy has been employed to avoid unnecessary lymph node dissection, because SLN negativity for carcinoma metastases may imply an extremely low possibility of non-SLN involvement. Pathological evaluation is essential, but standardized procedures have not yet been determined. Intraoperative consultation, either by frozen section (multiple slices are desirable) or touch imprint cytology, are usually very useful. Their accuracy, however, is variable and depends on the procedures used, but specificity is characteristically 100%, and the missed metastatic focus is always quite minute. After fixation, multiple sections, immuno-histochemistry, and their combination will be able to detect small metastatic foci more frequently. The clinical significance of small or submicro- or occult metastases have not yet been clarified, and further investigations are needed. If the SLN is positive for carcinoma metastases, both the procedure for detection and the size of the metastatic focus should be clarified on the pathological reports.http://www.sciencedirect.com/science/article/pii/S1015958409600476 |
| spellingShingle | Takuya Moriya Shin Usami Hiroshi Tada Atsuko Kasajima Kazuyuki Ishida Yoshiyuki Kariya Noriaki Ohuchi Hironobu Sasano Pathological Evaluation of Sentinel Lymph Nodes for Breast Cancer Asian Journal of Surgery |
| title | Pathological Evaluation of Sentinel Lymph Nodes for Breast Cancer |
| title_full | Pathological Evaluation of Sentinel Lymph Nodes for Breast Cancer |
| title_fullStr | Pathological Evaluation of Sentinel Lymph Nodes for Breast Cancer |
| title_full_unstemmed | Pathological Evaluation of Sentinel Lymph Nodes for Breast Cancer |
| title_short | Pathological Evaluation of Sentinel Lymph Nodes for Breast Cancer |
| title_sort | pathological evaluation of sentinel lymph nodes for breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1015958409600476 |
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