Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait
Abstract This study explored whether amygdala reactivity predicted the greed personality trait (GPT) using both task-based and resting-state functional connectivity analyses (ntotal = 452). In Cohort 1 (n = 83), task-based functional magnetic resonance imaging (t-fMRI) results from a region-of-inter...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-12-01
|
| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12993-023-00223-w |
| _version_ | 1797414442983489536 |
|---|---|
| author | Kun Deng Weipeng Jin Keying Jiang Zixi Li Hohjin Im Shuning Chen Hanxiao Du Shunping Guan Wei Ge Chuqiao Wei Bin Zhang Pinchun Wang Guang Zhao Chunhui Chen Liqing Liu Qiang Wang |
| author_facet | Kun Deng Weipeng Jin Keying Jiang Zixi Li Hohjin Im Shuning Chen Hanxiao Du Shunping Guan Wei Ge Chuqiao Wei Bin Zhang Pinchun Wang Guang Zhao Chunhui Chen Liqing Liu Qiang Wang |
| author_sort | Kun Deng |
| collection | DOAJ |
| description | Abstract This study explored whether amygdala reactivity predicted the greed personality trait (GPT) using both task-based and resting-state functional connectivity analyses (ntotal = 452). In Cohort 1 (n = 83), task-based functional magnetic resonance imaging (t-fMRI) results from a region-of-interest (ROI) analysis revealed no direct correlation between amygdala reactivity to fearful and angry faces and GPT. Instead, whole-brain analyses revealed GPT to robustly negatively vary with activations in the right ventromedial prefrontal cortex (vmPFC), supramarginal gyrus, and angular gyrus in the contrast of fearful + angry faces > shapes. Moreover, task-based psychophysiological interaction (PPI) analyses showed that the high GPT group showed weaker functional connectivity of the vmPFC seed with a top-down control network and visual pathways when processing fearful or angry faces compared to their lower GPT counterparts. In Cohort 2, resting-state functional connectivity (rs-FC) analyses indicated stronger connectivity between the vmPFC seed and the top-down control network and visual pathways in individuals with higher GPT. Comparing the two cohorts, bilateral amygdala seeds showed weaker associations with the top-down control network in the high group via PPI analyses in Cohort 1. Yet, they exhibited distinct rs-FC patterns in Cohort 2 (e.g., positive associations of GPT with the left amygdala-top-down network FC but negative associations with the right amygdala-visual pathway FC). The study underscores the role of the vmPFC and its functional connectivity in understanding GPT, rather than amygdala reactivity. |
| first_indexed | 2024-03-09T05:33:05Z |
| format | Article |
| id | doaj.art-4414b209a8364672909115ad381da0fa |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-03-09T05:33:05Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-4414b209a8364672909115ad381da0fa2023-12-03T12:30:56ZengBMCBehavioral and Brain Functions1744-90812023-12-0119111410.1186/s12993-023-00223-wReactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality traitKun Deng0Weipeng Jin1Keying Jiang2Zixi Li3Hohjin Im4Shuning Chen5Hanxiao Du6Shunping Guan7Wei Ge8Chuqiao Wei9Bin Zhang10Pinchun Wang11Guang Zhao12Chunhui Chen13Liqing Liu14Qiang Wang15Faculty of Psychology, Tianjin Normal UniversityDepartment of Neurosurgery, Tianjin Huanhu HospitalFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityDepartment of Psychological Science, University of CaliforniaFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityFaculty of Psychology, Tianjin Normal UniversityFaculty of Psychology, Tianjin Normal UniversityAbstract This study explored whether amygdala reactivity predicted the greed personality trait (GPT) using both task-based and resting-state functional connectivity analyses (ntotal = 452). In Cohort 1 (n = 83), task-based functional magnetic resonance imaging (t-fMRI) results from a region-of-interest (ROI) analysis revealed no direct correlation between amygdala reactivity to fearful and angry faces and GPT. Instead, whole-brain analyses revealed GPT to robustly negatively vary with activations in the right ventromedial prefrontal cortex (vmPFC), supramarginal gyrus, and angular gyrus in the contrast of fearful + angry faces > shapes. Moreover, task-based psychophysiological interaction (PPI) analyses showed that the high GPT group showed weaker functional connectivity of the vmPFC seed with a top-down control network and visual pathways when processing fearful or angry faces compared to their lower GPT counterparts. In Cohort 2, resting-state functional connectivity (rs-FC) analyses indicated stronger connectivity between the vmPFC seed and the top-down control network and visual pathways in individuals with higher GPT. Comparing the two cohorts, bilateral amygdala seeds showed weaker associations with the top-down control network in the high group via PPI analyses in Cohort 1. Yet, they exhibited distinct rs-FC patterns in Cohort 2 (e.g., positive associations of GPT with the left amygdala-top-down network FC but negative associations with the right amygdala-visual pathway FC). The study underscores the role of the vmPFC and its functional connectivity in understanding GPT, rather than amygdala reactivity.https://doi.org/10.1186/s12993-023-00223-wGreedAmygdalavmPFCPPIFunctional connectivity |
| spellingShingle | Kun Deng Weipeng Jin Keying Jiang Zixi Li Hohjin Im Shuning Chen Hanxiao Du Shunping Guan Wei Ge Chuqiao Wei Bin Zhang Pinchun Wang Guang Zhao Chunhui Chen Liqing Liu Qiang Wang Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait Behavioral and Brain Functions Greed Amygdala vmPFC PPI Functional connectivity |
| title | Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait |
| title_full | Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait |
| title_fullStr | Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait |
| title_full_unstemmed | Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait |
| title_short | Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait |
| title_sort | reactivity of the ventromedial prefrontal cortex but not the amygdala to negative emotion faces predicts greed personality trait |
| topic | Greed Amygdala vmPFC PPI Functional connectivity |
| url | https://doi.org/10.1186/s12993-023-00223-w |
| work_keys_str_mv | AT kundeng reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT weipengjin reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT keyingjiang reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT zixili reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT hohjinim reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT shuningchen reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT hanxiaodu reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT shunpingguan reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT weige reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT chuqiaowei reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT binzhang reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT pinchunwang reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT guangzhao reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT chunhuichen reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT liqingliu reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait AT qiangwang reactivityoftheventromedialprefrontalcortexbutnottheamygdalatonegativeemotionfacespredictsgreedpersonalitytrait |