Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation

Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation

Acyloxydiene–Fe(CO)3 complexes can act as enzyme-triggered CO-releasing molecules (ET-CORMs). Their biological activity strongly depends on the mother compound from which they are derived, i.e. cyclohexenone or cyclohexanedione, and on the position of the ester functionality they harbour. The presen...

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Bibliographic Details
Main Authors: E. Stamellou, D. Storz, S. Botov, E. Ntasis, J. Wedel, S. Sollazzo, B.K. Krämer, W. van Son, M. Seelen, H.G. Schmalz, A. Schmidt, M. Hafner, B.A. Yard
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Endothelial cells
Carbon monoxide
Adhesion molecules
Enzyme-triggered CORMs
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000731

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