Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials
Highlights 1. Metformin therapy regresses LVH by approximately 10 g/m2 in non-diabetic patients after 12 months of use (SMCC = −0.63, 95% CI − 1.23; − 0.04, p = 0.04). 2. Metformin therapy was associated with a modest (2–3%) but greater overall improvement in LVEF. 3. Higher dose (> 1000 mg/day)...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-022-02845-w |
| _version_ | 1818064690958303232 |
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| author | Ahmed M. Kamel Nirmeen Sabry Samar Farid |
| author_facet | Ahmed M. Kamel Nirmeen Sabry Samar Farid |
| author_sort | Ahmed M. Kamel |
| collection | DOAJ |
| description | Highlights 1. Metformin therapy regresses LVH by approximately 10 g/m2 in non-diabetic patients after 12 months of use (SMCC = −0.63, 95% CI − 1.23; − 0.04, p = 0.04). 2. Metformin therapy was associated with a modest (2–3%) but greater overall improvement in LVEF. 3. Higher dose (> 1000 mg/day) and longer treatment duration were associated with a significant effect for metformin on LVMI and LVEF. 4. Metformin use in HF patients was associated with an absolute increase of 3.21% in LVEF (SMCC = 0.23; 95% CI 0.1; 0.36, P = 0.004). |
| first_indexed | 2024-12-10T14:40:01Z |
| format | Article |
| id | doaj.art-4418d1d34b4b4340ae4ff2c85d9c6b2f |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-10T14:40:01Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-4418d1d34b4b4340ae4ff2c85d9c6b2f2022-12-22T01:44:42ZengBMCBMC Cardiovascular Disorders1471-22612022-09-0122111810.1186/s12872-022-02845-wEffect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trialsAhmed M. Kamel0Nirmeen Sabry1Samar Farid2Clinical Pharmacy Department, Faculty of Pharmacy, Cairo UniversityClinical Pharmacy Department, Faculty of Pharmacy, Cairo UniversityClinical Pharmacy Department, Faculty of Pharmacy, Cairo UniversityHighlights 1. Metformin therapy regresses LVH by approximately 10 g/m2 in non-diabetic patients after 12 months of use (SMCC = −0.63, 95% CI − 1.23; − 0.04, p = 0.04). 2. Metformin therapy was associated with a modest (2–3%) but greater overall improvement in LVEF. 3. Higher dose (> 1000 mg/day) and longer treatment duration were associated with a significant effect for metformin on LVMI and LVEF. 4. Metformin use in HF patients was associated with an absolute increase of 3.21% in LVEF (SMCC = 0.23; 95% CI 0.1; 0.36, P = 0.004).https://doi.org/10.1186/s12872-022-02845-wLeft ventricular mass indexMetforminLeft ventricular ejection fractionCardiovascular diseaseSystematic reviewMeta-analysis |
| spellingShingle | Ahmed M. Kamel Nirmeen Sabry Samar Farid Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials BMC Cardiovascular Disorders Left ventricular mass index Metformin Left ventricular ejection fraction Cardiovascular disease Systematic review Meta-analysis |
| title | Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials |
| title_full | Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials |
| title_fullStr | Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials |
| title_full_unstemmed | Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials |
| title_short | Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials |
| title_sort | effect of metformin on left ventricular mass and functional parameters in non diabetic patients a meta analysis of randomized clinical trials |
| topic | Left ventricular mass index Metformin Left ventricular ejection fraction Cardiovascular disease Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12872-022-02845-w |
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