Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9

PRDM9, a histone lysine methyltransferase, is a key determinant of the localization of meiotic recombination hot spots in humans and mice and the only vertebrate protein known to be involved in hybrid sterility. Here, we report the crystal structure of the PRDM9 methyltransferase domain in complex w...

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Bibliographic Details
Main Authors: Hong Wu, Nikolas Mathioudakis, Boubou Diagouraga, Aiping Dong, Ludmila Dombrovski, Frédéric Baudat, Stephen Cusack, Bernard de Massy, Jan Kadlec
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713004762

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