Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes
Flavivirus replication in host cells requires the formation of replication and assembly complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These complexes consist of an ER membrane, viral proteins, and host proteins. Genome-wide investigations have identified a number of E...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/8/3/148 |
| _version_ | 1811297999936028672 |
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| author | Hussin A. Rothan Mukesh Kumar |
| author_facet | Hussin A. Rothan Mukesh Kumar |
| author_sort | Hussin A. Rothan |
| collection | DOAJ |
| description | Flavivirus replication in host cells requires the formation of replication and assembly complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These complexes consist of an ER membrane, viral proteins, and host proteins. Genome-wide investigations have identified a number of ER multiprotein complexes as vital factors for flavivirus replication. The detailed mechanisms of the role of ER complexes in flavivirus replication are still largely elusive. This review highlights the fact that the ER multiprotein complexes are crucial for the formation of flavivirus replication and assembly complexes, and the ER complexes could be considered as a target for developing successful broad-spectrum anti-flavivirus drugs. |
| first_indexed | 2024-04-13T06:12:29Z |
| format | Article |
| id | doaj.art-441a9b4719d24e52b5f041f76ea9ca80 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-13T06:12:29Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-441a9b4719d24e52b5f041f76ea9ca802022-12-22T02:58:57ZengMDPI AGPathogens2076-08172019-09-018314810.3390/pathogens8030148pathogens8030148Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly ComplexesHussin A. Rothan0Mukesh Kumar1Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USADepartment of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USAFlavivirus replication in host cells requires the formation of replication and assembly complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These complexes consist of an ER membrane, viral proteins, and host proteins. Genome-wide investigations have identified a number of ER multiprotein complexes as vital factors for flavivirus replication. The detailed mechanisms of the role of ER complexes in flavivirus replication are still largely elusive. This review highlights the fact that the ER multiprotein complexes are crucial for the formation of flavivirus replication and assembly complexes, and the ER complexes could be considered as a target for developing successful broad-spectrum anti-flavivirus drugs.https://www.mdpi.com/2076-0817/8/3/148flavivirusvirus replication complexendoplasmic reticulumhost factors |
| spellingShingle | Hussin A. Rothan Mukesh Kumar Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes Pathogens flavivirus virus replication complex endoplasmic reticulum host factors |
| title | Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes |
| title_full | Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes |
| title_fullStr | Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes |
| title_full_unstemmed | Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes |
| title_short | Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes |
| title_sort | role of endoplasmic reticulum associated proteins in flavivirus replication and assembly complexes |
| topic | flavivirus virus replication complex endoplasmic reticulum host factors |
| url | https://www.mdpi.com/2076-0817/8/3/148 |
| work_keys_str_mv | AT hussinarothan roleofendoplasmicreticulumassociatedproteinsinflavivirusreplicationandassemblycomplexes AT mukeshkumar roleofendoplasmicreticulumassociatedproteinsinflavivirusreplicationandassemblycomplexes |