Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infections
Background: The alarming spread of antibiotic-resistant bacteria causing healthcare-associated infections has been extensively reported in recent medical literature. Aims: To compare trends in antimicrobial consumption and development of resistance among isolates of Acinetobacter spp. and Pseudomo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-12-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=1894 |
| _version_ | 1828029621121056768 |
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| author | Zorana M. Djordjevic Marko M. Folic Slobodan M. Jankovic |
| author_facet | Zorana M. Djordjevic Marko M. Folic Slobodan M. Jankovic |
| author_sort | Zorana M. Djordjevic |
| collection | DOAJ |
| description | Background: The alarming spread of antibiotic-resistant bacteria causing healthcare-associated infections has been extensively reported in recent medical literature.
Aims: To compare trends in antimicrobial consumption and development of resistance among isolates of Acinetobacter spp. and Pseudomonas aeruginosa that cause hospital infections.
Study Design: Cross-sectional study.
Methods: A study was conducted in a tertiary healthcare institution in central Serbia, during the 7-year period between January 2009 and December 2015. The incidence rate of infections caused by Acinetobacter or Pseudomonas, as well as their resistance density to commonly used antibiotics, were calculated. Utilization of antibiotics was expressed as the number of defined daily doses per 1000 patient-days.
Results: A statistically significant increase in resistance density in 2015 compared to the first year of observation was noted for Acinetobacter, but not for Pseudomonas, to third-generation cephalosporins (p=0.008), aminoglycosides (p=0.005), carbapenems (p=0.003), piperacillin/tazobactam (p=0.025), ampicillin/sulbactam (p=0.009) and tigecycline (p=0.048).
Conclusion: Our study showed that there is an association between the resistance density of Acinetobacter spp. and utilization of carbapenems, tigecycline and aminoglycosides. A multifaceted intervention is needed to decrease the incidence rate of Acinetobacter and Pseudomonas hospital infections, as well as their resistance density to available antibiotics |
| first_indexed | 2024-04-10T14:14:02Z |
| format | Article |
| id | doaj.art-441b5825f5474ce79bebfcee89702f0e |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T14:14:02Z |
| publishDate | 2017-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-441b5825f5474ce79bebfcee89702f0e2023-02-15T16:09:37ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312017-12-0134652753310.4274/balkanmedj.2016.1844Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial InfectionsZorana M. Djordjevic0Marko M. Folic1Slobodan M. Jankovic2Clinic of Control Hospital Infections, Kragujevac Centre Clinical, Kragujevac, SerbiaClinic of Pharmacology, Kragujevac Centre Clinical, Kragujevac, SerbiaKragujevac University School of Medicine, Kragujevac, SerbiaBackground: The alarming spread of antibiotic-resistant bacteria causing healthcare-associated infections has been extensively reported in recent medical literature. Aims: To compare trends in antimicrobial consumption and development of resistance among isolates of Acinetobacter spp. and Pseudomonas aeruginosa that cause hospital infections. Study Design: Cross-sectional study. Methods: A study was conducted in a tertiary healthcare institution in central Serbia, during the 7-year period between January 2009 and December 2015. The incidence rate of infections caused by Acinetobacter or Pseudomonas, as well as their resistance density to commonly used antibiotics, were calculated. Utilization of antibiotics was expressed as the number of defined daily doses per 1000 patient-days. Results: A statistically significant increase in resistance density in 2015 compared to the first year of observation was noted for Acinetobacter, but not for Pseudomonas, to third-generation cephalosporins (p=0.008), aminoglycosides (p=0.005), carbapenems (p=0.003), piperacillin/tazobactam (p=0.025), ampicillin/sulbactam (p=0.009) and tigecycline (p=0.048). Conclusion: Our study showed that there is an association between the resistance density of Acinetobacter spp. and utilization of carbapenems, tigecycline and aminoglycosides. A multifaceted intervention is needed to decrease the incidence rate of Acinetobacter and Pseudomonas hospital infections, as well as their resistance density to available antibioticshttp://balkanmedicaljournal.org/text.php?lang=en&id=1894Nosocomial infectionsPseudomonas aeruginosaAcinetobacterantimicrobial resistance |
| spellingShingle | Zorana M. Djordjevic Marko M. Folic Slobodan M. Jankovic Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infections Balkan Medical Journal Nosocomial infections Pseudomonas aeruginosa Acinetobacter antimicrobial resistance |
| title | Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infections |
| title_full | Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infections |
| title_fullStr | Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infections |
| title_full_unstemmed | Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infections |
| title_short | Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infections |
| title_sort | previous antibiotic exposure and antimicrobial resistance patterns of acinetobacter spp and pseudomonas aeruginosa isolated from patients with nosocomial infections |
| topic | Nosocomial infections Pseudomonas aeruginosa Acinetobacter antimicrobial resistance |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=1894 |
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