Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution
Adaptive responses to hypoxia are involved in the progression of lung cancer and pulmonary fibrosis. However, it has not been pointed out that hypoxia may be the link between these diseases. As tumors or scars expand, a lack of oxygen results in the activation of the hypoxia response, promoting cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/15/8335 |
| _version_ | 1797525436899524608 |
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| author | Yair Romero Arnoldo Aquino-Gálvez |
| author_facet | Yair Romero Arnoldo Aquino-Gálvez |
| author_sort | Yair Romero |
| collection | DOAJ |
| description | Adaptive responses to hypoxia are involved in the progression of lung cancer and pulmonary fibrosis. However, it has not been pointed out that hypoxia may be the link between these diseases. As tumors or scars expand, a lack of oxygen results in the activation of the hypoxia response, promoting cell survival even during chronic conditions. The role of hypoxia-inducible factors (HIFs) as master regulators of this adaptation is crucial in both lung cancer and idiopathic pulmonary fibrosis, which have shown the active transcriptional signature of this pathway. Emerging evidence suggests that interconnected feedback loops such as metabolic changes, fibroblast differentiation or extracellular matrix remodeling contribute to HIF overactivation, making it an irreversible phenomenon. This review will focus on the role of HIF signaling and its possible overlapping in order to identify new opportunities in therapy and regeneration. |
| first_indexed | 2024-03-10T09:13:52Z |
| format | Article |
| id | doaj.art-441b63344e084b09a284faaed6b2791e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:13:52Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-441b63344e084b09a284faaed6b2791e2023-11-22T05:46:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012215833510.3390/ijms22158335Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the SolutionYair Romero0Arnoldo Aquino-Gálvez1Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoInstituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City 14080, MexicoAdaptive responses to hypoxia are involved in the progression of lung cancer and pulmonary fibrosis. However, it has not been pointed out that hypoxia may be the link between these diseases. As tumors or scars expand, a lack of oxygen results in the activation of the hypoxia response, promoting cell survival even during chronic conditions. The role of hypoxia-inducible factors (HIFs) as master regulators of this adaptation is crucial in both lung cancer and idiopathic pulmonary fibrosis, which have shown the active transcriptional signature of this pathway. Emerging evidence suggests that interconnected feedback loops such as metabolic changes, fibroblast differentiation or extracellular matrix remodeling contribute to HIF overactivation, making it an irreversible phenomenon. This review will focus on the role of HIF signaling and its possible overlapping in order to identify new opportunities in therapy and regeneration.https://www.mdpi.com/1422-0067/22/15/8335hypoxia-inducible factorslung canceridiopathic pulmonary fibrosisregeneration |
| spellingShingle | Yair Romero Arnoldo Aquino-Gálvez Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution International Journal of Molecular Sciences hypoxia-inducible factors lung cancer idiopathic pulmonary fibrosis regeneration |
| title | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
| title_full | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
| title_fullStr | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
| title_full_unstemmed | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
| title_short | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
| title_sort | hypoxia in cancer and fibrosis part of the problem and part of the solution |
| topic | hypoxia-inducible factors lung cancer idiopathic pulmonary fibrosis regeneration |
| url | https://www.mdpi.com/1422-0067/22/15/8335 |
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