Measuring anxiety disorder in bipolar disorder using EVestG: broad impact of medication groups
ObjectivesAnxiety disorder is present in approximately half of all bipolar disorder (BD) patients. There are neurologic bases for the comorbidity of balance (vestibular) disorders and anxiety. Our objective is to use electrovestibulography (EVestG), which is predominantly a measure of vestibular neu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1303287/full |
| _version_ | 1827381155674980352 |
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| author | Brian J. Lithgow Brian J. Lithgow Zahra Moussavi |
| author_facet | Brian J. Lithgow Brian J. Lithgow Zahra Moussavi |
| author_sort | Brian J. Lithgow |
| collection | DOAJ |
| description | ObjectivesAnxiety disorder is present in approximately half of all bipolar disorder (BD) patients. There are neurologic bases for the comorbidity of balance (vestibular) disorders and anxiety. Our objective is to use electrovestibulography (EVestG), which is predominantly a measure of vestibular neural activity to not only quantitatively detect and measure comorbid anxiety disorder but also to quantitatively measure the impacts of anti-depressant, anti-psychotic, and mood stabilizer medication groups on anxiety measures in BD patients.MethodsIn a population of 50 (24 with anxiety disorder) depressive phase BD patients, EVestG signals were measured. Participants were labeled depression-wise as anxious or non-anxious using standard questionnaires. Analyses were conducted on the whole dataset as well as on matched (age/gender/MADRS) and “modeled medication-free” subsets. Modulations of the low-frequency EVestG firing pattern data were measured.FindingsFor BD, the main anxious minus non-anxious difference was the presence of an increase in spectral power proximal to 8–9 Hz, which was best attenuated by mood stabilizers.NoveltyThis is the first study to use an oto-acoustic physiological measure to quantify anxiety disorder in BD wherein it appears to manifest as a peak proximal to 8–9 Hz which we hypothesize as likely linked to hippocampal theta. |
| first_indexed | 2024-03-08T13:50:09Z |
| format | Article |
| id | doaj.art-441c55aaeab040b9b1378b4fd95f0fc8 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-08T13:50:09Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-441c55aaeab040b9b1378b4fd95f0fc82024-01-16T04:12:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-01-011410.3389/fneur.2023.13032871303287Measuring anxiety disorder in bipolar disorder using EVestG: broad impact of medication groupsBrian J. Lithgow0Brian J. Lithgow1Zahra Moussavi2Diagnostic and Neurosignal Processing Research Laboratory, Biomedical Engineering Program, University of Manitoba, Riverview Health Centre, Winnipeg, MB, CanadaMonash Alfred Psychiatry Research Centre, Prahran, VIC, AustraliaDiagnostic and Neurosignal Processing Research Laboratory, Biomedical Engineering Program, University of Manitoba, Riverview Health Centre, Winnipeg, MB, CanadaObjectivesAnxiety disorder is present in approximately half of all bipolar disorder (BD) patients. There are neurologic bases for the comorbidity of balance (vestibular) disorders and anxiety. Our objective is to use electrovestibulography (EVestG), which is predominantly a measure of vestibular neural activity to not only quantitatively detect and measure comorbid anxiety disorder but also to quantitatively measure the impacts of anti-depressant, anti-psychotic, and mood stabilizer medication groups on anxiety measures in BD patients.MethodsIn a population of 50 (24 with anxiety disorder) depressive phase BD patients, EVestG signals were measured. Participants were labeled depression-wise as anxious or non-anxious using standard questionnaires. Analyses were conducted on the whole dataset as well as on matched (age/gender/MADRS) and “modeled medication-free” subsets. Modulations of the low-frequency EVestG firing pattern data were measured.FindingsFor BD, the main anxious minus non-anxious difference was the presence of an increase in spectral power proximal to 8–9 Hz, which was best attenuated by mood stabilizers.NoveltyThis is the first study to use an oto-acoustic physiological measure to quantify anxiety disorder in BD wherein it appears to manifest as a peak proximal to 8–9 Hz which we hypothesize as likely linked to hippocampal theta.https://www.frontiersin.org/articles/10.3389/fneur.2023.1303287/fulldepressionelectrovestibulographybiomarkersanti-depressantsanti-psychoticsmood stabilizers |
| spellingShingle | Brian J. Lithgow Brian J. Lithgow Zahra Moussavi Measuring anxiety disorder in bipolar disorder using EVestG: broad impact of medication groups Frontiers in Neurology depression electrovestibulography biomarkers anti-depressants anti-psychotics mood stabilizers |
| title | Measuring anxiety disorder in bipolar disorder using EVestG: broad impact of medication groups |
| title_full | Measuring anxiety disorder in bipolar disorder using EVestG: broad impact of medication groups |
| title_fullStr | Measuring anxiety disorder in bipolar disorder using EVestG: broad impact of medication groups |
| title_full_unstemmed | Measuring anxiety disorder in bipolar disorder using EVestG: broad impact of medication groups |
| title_short | Measuring anxiety disorder in bipolar disorder using EVestG: broad impact of medication groups |
| title_sort | measuring anxiety disorder in bipolar disorder using evestg broad impact of medication groups |
| topic | depression electrovestibulography biomarkers anti-depressants anti-psychotics mood stabilizers |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1303287/full |
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