Association of Various Factors in Terms of Pathological Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
Objective: To analyze the association of various factors in terms of pathological response among breast cancer patients. Study Design: Cross-sectional study. Place and Duration of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, from Jan 2019 to Jun 2020. Method...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-05-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/6651 |
| _version_ | 1797826682282835968 |
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| author | Anum Zargham Riaz Ahmad Mussavir Hussain Bangash Umair Tufail Ibtisam . Anil Babar |
| author_facet | Anum Zargham Riaz Ahmad Mussavir Hussain Bangash Umair Tufail Ibtisam . Anil Babar |
| author_sort | Anum Zargham |
| collection | DOAJ |
| description |
Objective: To analyze the association of various factors in terms of pathological response among breast cancer patients.
Study Design: Cross-sectional study.
Place and Duration of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, from Jan 2019 to Jun 2020.
Methodology: This study was conducted on 82 female patients with advanced breast cancer who required neo-adjuvant chemotherapy followed by surgical tumour resection. The pathological response was classed as complete, partial, and no response based on histological findings on resected tumour sample. In addition, the age of the patient, stage of disease at presentation, intrinsic (molecular) subtypes and pathological subtype were the factors correlated with response to treatment in the target population.
Results: A total of 82 female patients were included in the final analysis. The mean age of the patients was 47.421±8.857 years. 27(32.9%) had a complete pathological response, 34(41.5%) had partial, and 21(25.6%) had no response to the neoadjuvant therapy. Intrinsic subtypes of the tumour were statistically significantly associated with pathological response to neoadjuvant therapy (p-value<0.05) in our study participants.
Conclusion: Considerable number of patients with advanced breast cancer showed pathological responses to neoadjuvant chemotherapy. In addition, intrinsic subtyping significantly predicted pathological response to therapy in our patients, with triple-negative patients having more chances of complete response to neoadjuvant chemotherapy.
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| first_indexed | 2024-04-09T12:36:19Z |
| format | Article |
| id | doaj.art-441d55673d8644ac83d6cff0fa9ba9a5 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-04-09T12:36:19Z |
| publishDate | 2023-05-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-441d55673d8644ac83d6cff0fa9ba9a52023-05-15T09:44:17ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-05-0173210.51253/pafmj.v73i2.6651Association of Various Factors in Terms of Pathological Response in Breast Cancer Patients Receiving Neoadjuvant ChemotherapyAnum Zargham0Riaz Ahmad1Mussavir Hussain Bangash2Umair Tufail3Ibtisam .4Anil Babar5Fauji Foundation Hospital, Rawalpindi PakistanCombined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanCombined Military Hospital, Multan/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanCombined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanQueen Elizabeth Hospital, Birmingham, United Kingdom England Objective: To analyze the association of various factors in terms of pathological response among breast cancer patients. Study Design: Cross-sectional study. Place and Duration of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, from Jan 2019 to Jun 2020. Methodology: This study was conducted on 82 female patients with advanced breast cancer who required neo-adjuvant chemotherapy followed by surgical tumour resection. The pathological response was classed as complete, partial, and no response based on histological findings on resected tumour sample. In addition, the age of the patient, stage of disease at presentation, intrinsic (molecular) subtypes and pathological subtype were the factors correlated with response to treatment in the target population. Results: A total of 82 female patients were included in the final analysis. The mean age of the patients was 47.421±8.857 years. 27(32.9%) had a complete pathological response, 34(41.5%) had partial, and 21(25.6%) had no response to the neoadjuvant therapy. Intrinsic subtypes of the tumour were statistically significantly associated with pathological response to neoadjuvant therapy (p-value<0.05) in our study participants. Conclusion: Considerable number of patients with advanced breast cancer showed pathological responses to neoadjuvant chemotherapy. In addition, intrinsic subtyping significantly predicted pathological response to therapy in our patients, with triple-negative patients having more chances of complete response to neoadjuvant chemotherapy. https://www.pafmj.org/index.php/PAFMJ/article/view/6651Breast cancerNeo-adjuvant chemotherapyPathological response |
| spellingShingle | Anum Zargham Riaz Ahmad Mussavir Hussain Bangash Umair Tufail Ibtisam . Anil Babar Association of Various Factors in Terms of Pathological Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Pakistan Armed Forces Medical Journal Breast cancer Neo-adjuvant chemotherapy Pathological response |
| title | Association of Various Factors in Terms of Pathological Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_full | Association of Various Factors in Terms of Pathological Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_fullStr | Association of Various Factors in Terms of Pathological Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_full_unstemmed | Association of Various Factors in Terms of Pathological Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_short | Association of Various Factors in Terms of Pathological Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_sort | association of various factors in terms of pathological response in breast cancer patients receiving neoadjuvant chemotherapy |
| topic | Breast cancer Neo-adjuvant chemotherapy Pathological response |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/6651 |
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