Prevalence of serum antibodies to TORCH infection in the first trimester of the pregnancy in Kashan, Iran
Introduction:TORCH infections causing via Toxoplasma gondii, other microorganisms (e.g., Treponema pallidum), Rubella virus, Cytomegalovirus (CMV) and the Herpes Simplex Virus (HSV) types 1 and 2 during the first trimester of pregnancy can lead to severe fetal anomalies or even fetal loss. The curre...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-03-01
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| Series: | Iranian Journal of Neonatology |
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| Online Access: | http://ijn.mums.ac.ir/publisher?_action=publish&article=4149&related_issue=627 |
| _version_ | 1818901004618301440 |
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| author | sareh bagheri josheghani Rezvan Moniri Fatemeh Baghbani Taheri |
| author_facet | sareh bagheri josheghani Rezvan Moniri Fatemeh Baghbani Taheri |
| author_sort | sareh bagheri josheghani |
| collection | DOAJ |
| description | Introduction:TORCH infections causing via Toxoplasma gondii, other microorganisms (e.g., Treponema pallidum), Rubella virus, Cytomegalovirus (CMV) and the Herpes Simplex Virus (HSV) types 1 and 2 during the first trimester of pregnancy can lead to severe fetal anomalies or even fetal loss. The current study determined the serological data of TORCH infections in women who were in their first trimesters of pregnancy.This descriptive study was carried out on 80 pregnant women in their first trimester in Kashan, Iran.
Methods: To detect specific IgM antibodies and specific IgG antibodies against the TORCH infections via ELISA, Sera were collected from the pregnant women.
Results: The specific IgG antibodies were found to be positive in 30(37.5%) cases for toxoplasmosis, in 74 (92.5%) cases for the Rubella virus, in 79(98.8%) cases for CMV and in 73 samples (91.3%) for the HSV types 1 and 2 infection. 3.8% of cases were found to be seropositive for Toxoplasma IgM antibody (95% CI, 0.38-7.9), 5% were positive for CMV IgM antibody (95% CI, 0.23-9.77) and 7.5% were positive for the HSV IgM antibody (95% CI, 1.8-13.2). 63.8% of pregnant women were at risk for at least to one of the TORCH agents.
Conclusion: This study showed a high prevalence of infections caused by TORCH agents among pregnant women. Therefore, national screening programmed is necessary to screen the TORCH infections routinely and to prevent and treat congenital TORCH infection |
| first_indexed | 2024-12-19T20:12:52Z |
| format | Article |
| id | doaj.art-4420af31d07048cdab6241561acad52d |
| institution | Directory Open Access Journal |
| issn | 2251-7510 2322-2158 |
| language | English |
| last_indexed | 2024-12-19T20:12:52Z |
| publishDate | 2015-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neonatology |
| spelling | doaj.art-4420af31d07048cdab6241561acad52d2022-12-21T20:07:15ZengMashhad University of Medical SciencesIranian Journal of Neonatology2251-75102322-21582015-03-0161812Prevalence of serum antibodies to TORCH infection in the first trimester of the pregnancy in Kashan, Iransareh bagheri josheghani0Rezvan Moniri1Fatemeh Baghbani Taheri2Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IranDepartment of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, IranRefrence Labratory, Kashan University of Medical Sciences, Kashan, Iran.Introduction:TORCH infections causing via Toxoplasma gondii, other microorganisms (e.g., Treponema pallidum), Rubella virus, Cytomegalovirus (CMV) and the Herpes Simplex Virus (HSV) types 1 and 2 during the first trimester of pregnancy can lead to severe fetal anomalies or even fetal loss. The current study determined the serological data of TORCH infections in women who were in their first trimesters of pregnancy.This descriptive study was carried out on 80 pregnant women in their first trimester in Kashan, Iran. Methods: To detect specific IgM antibodies and specific IgG antibodies against the TORCH infections via ELISA, Sera were collected from the pregnant women. Results: The specific IgG antibodies were found to be positive in 30(37.5%) cases for toxoplasmosis, in 74 (92.5%) cases for the Rubella virus, in 79(98.8%) cases for CMV and in 73 samples (91.3%) for the HSV types 1 and 2 infection. 3.8% of cases were found to be seropositive for Toxoplasma IgM antibody (95% CI, 0.38-7.9), 5% were positive for CMV IgM antibody (95% CI, 0.23-9.77) and 7.5% were positive for the HSV IgM antibody (95% CI, 1.8-13.2). 63.8% of pregnant women were at risk for at least to one of the TORCH agents. Conclusion: This study showed a high prevalence of infections caused by TORCH agents among pregnant women. Therefore, national screening programmed is necessary to screen the TORCH infections routinely and to prevent and treat congenital TORCH infectionhttp://ijn.mums.ac.ir/publisher?_action=publish&article=4149&related_issue=627TORCH; IgM; IgG; Antibodies; Pregnant |
| spellingShingle | sareh bagheri josheghani Rezvan Moniri Fatemeh Baghbani Taheri Prevalence of serum antibodies to TORCH infection in the first trimester of the pregnancy in Kashan, Iran Iranian Journal of Neonatology TORCH; IgM; IgG; Antibodies; Pregnant |
| title | Prevalence of serum antibodies to TORCH infection in the first trimester of the pregnancy in Kashan, Iran |
| title_full | Prevalence of serum antibodies to TORCH infection in the first trimester of the pregnancy in Kashan, Iran |
| title_fullStr | Prevalence of serum antibodies to TORCH infection in the first trimester of the pregnancy in Kashan, Iran |
| title_full_unstemmed | Prevalence of serum antibodies to TORCH infection in the first trimester of the pregnancy in Kashan, Iran |
| title_short | Prevalence of serum antibodies to TORCH infection in the first trimester of the pregnancy in Kashan, Iran |
| title_sort | prevalence of serum antibodies to torch infection in the first trimester of the pregnancy in kashan iran |
| topic | TORCH; IgM; IgG; Antibodies; Pregnant |
| url | http://ijn.mums.ac.ir/publisher?_action=publish&article=4149&related_issue=627 |
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