Advances in neural circuit mechanism in Parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative disease with strong heterogeneity of clinical symptoms and progressive aggravation. The core pathological feature is the apoptosis of dopaminergic neurons in substantia nigra and striatum, but this pathological feature can only explain part...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2020-12-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2247 |
| _version_ | 1819075151514304512 |
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| author | Chi XIONG Chao⁃shi NIU |
| author_facet | Chi XIONG Chao⁃shi NIU |
| author_sort | Chi XIONG |
| collection | DOAJ |
| description | Parkinson's disease (PD) is a common neurodegenerative disease with strong heterogeneity of clinical symptoms and progressive aggravation. The core pathological feature is the apoptosis of dopaminergic neurons in substantia nigra and striatum, but this pathological feature can only explain part of the symptom. With the development of electrophysiological recording, fMRI, optogenetics and other technologies, it has been found that neural circuit dysfunction after dopaminergic neuron apoptosis is an important mechanism for the occurrence and development of PD, as well as many therapeutic measures such as deep brain stimulation (DBS) intervention target. This article reviews the research progress of PD neural circuit mechanism in recent years, including common symptoms of PD, neural circuit models, and abnormal electrical activity patterns, to provide ideas for clinical research.
DOI：10.3969/j.issn.1672⁃6731.2020.12.002 |
| first_indexed | 2024-12-21T18:20:51Z |
| format | Article |
| id | doaj.art-442126204c2746aab024a6aec26bf640 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-21T18:20:51Z |
| publishDate | 2020-12-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-442126204c2746aab024a6aec26bf6402022-12-21T18:54:33ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312020-12-012012103210362202Advances in neural circuit mechanism in Parkinson's diseaseChi XIONGChao⁃shi NIUParkinson's disease (PD) is a common neurodegenerative disease with strong heterogeneity of clinical symptoms and progressive aggravation. The core pathological feature is the apoptosis of dopaminergic neurons in substantia nigra and striatum, but this pathological feature can only explain part of the symptom. With the development of electrophysiological recording, fMRI, optogenetics and other technologies, it has been found that neural circuit dysfunction after dopaminergic neuron apoptosis is an important mechanism for the occurrence and development of PD, as well as many therapeutic measures such as deep brain stimulation (DBS) intervention target. This article reviews the research progress of PD neural circuit mechanism in recent years, including common symptoms of PD, neural circuit models, and abnormal electrical activity patterns, to provide ideas for clinical research. DOI：10.3969/j.issn.1672⁃6731.2020.12.002http://www.cjcnn.org/index.php/cjcnn/article/view/2247parkinson diseaseneuronsbasal gangliadeep brain stimulationreview |
| spellingShingle | Chi XIONG Chao⁃shi NIU Advances in neural circuit mechanism in Parkinson's disease Chinese Journal of Contemporary Neurology and Neurosurgery parkinson disease neurons basal ganglia deep brain stimulation review |
| title | Advances in neural circuit mechanism in Parkinson's disease |
| title_full | Advances in neural circuit mechanism in Parkinson's disease |
| title_fullStr | Advances in neural circuit mechanism in Parkinson's disease |
| title_full_unstemmed | Advances in neural circuit mechanism in Parkinson's disease |
| title_short | Advances in neural circuit mechanism in Parkinson's disease |
| title_sort | advances in neural circuit mechanism in parkinson s disease |
| topic | parkinson disease neurons basal ganglia deep brain stimulation review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2247 |
| work_keys_str_mv | AT chixiong advancesinneuralcircuitmechanisminparkinsonsdisease AT chaoshiniu advancesinneuralcircuitmechanisminparkinsonsdisease |