Ibrutinib-associated cutaneous mucormycosis due to an species: report of a case and review of the literature
The use of ibrutinib, a Bruton tyrosine kinase inhibitor, has been associated with invasive fungal infections (IFIs). We describe a case of Apophysomyces infection associated with long-term use of ibrutinib for the treatment of chronic lymphocytic leukemia as well as perform a literature review of M...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-03-01
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| Series: | Therapeutic Advances in Infectious Disease |
| Online Access: | https://doi.org/10.1177/20499361241241199 |
| _version_ | 1797243079516749824 |
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| author | Trung Minh Nguyen Eva Amenta Lynne Chapman Sarvari Yellapragada Bhuvaneswari Krishnan Jonathan Lim Richard J. Hamill |
| author_facet | Trung Minh Nguyen Eva Amenta Lynne Chapman Sarvari Yellapragada Bhuvaneswari Krishnan Jonathan Lim Richard J. Hamill |
| author_sort | Trung Minh Nguyen |
| collection | DOAJ |
| description | The use of ibrutinib, a Bruton tyrosine kinase inhibitor, has been associated with invasive fungal infections (IFIs). We describe a case of Apophysomyces infection associated with long-term use of ibrutinib for the treatment of chronic lymphocytic leukemia as well as perform a literature review of Mucormycosis infections in patients on ibrutinib. Our review found that the onset of IFI can occur within months to years of starting tyrosine kinase inhibitors. These reports provide a more complete picture of the risk of IFI while patients are on ibrutinib. Our case also demonstrates the utility of molecular techniques in the diagnosis of IFI, as the diagnosis was made using 28S rDNA/internal transcribed spacer PCR. |
| first_indexed | 2024-04-24T18:49:25Z |
| format | Article |
| id | doaj.art-4425da1286e440d3a6ea298f9613302d |
| institution | Directory Open Access Journal |
| issn | 2049-937X |
| language | English |
| last_indexed | 2024-04-24T18:49:25Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Infectious Disease |
| spelling | doaj.art-4425da1286e440d3a6ea298f9613302d2024-03-27T02:03:30ZengSAGE PublishingTherapeutic Advances in Infectious Disease2049-937X2024-03-011110.1177/20499361241241199Ibrutinib-associated cutaneous mucormycosis due to an species: report of a case and review of the literatureTrung Minh NguyenEva AmentaLynne ChapmanSarvari YellapragadaBhuvaneswari KrishnanJonathan LimRichard J. HamillThe use of ibrutinib, a Bruton tyrosine kinase inhibitor, has been associated with invasive fungal infections (IFIs). We describe a case of Apophysomyces infection associated with long-term use of ibrutinib for the treatment of chronic lymphocytic leukemia as well as perform a literature review of Mucormycosis infections in patients on ibrutinib. Our review found that the onset of IFI can occur within months to years of starting tyrosine kinase inhibitors. These reports provide a more complete picture of the risk of IFI while patients are on ibrutinib. Our case also demonstrates the utility of molecular techniques in the diagnosis of IFI, as the diagnosis was made using 28S rDNA/internal transcribed spacer PCR.https://doi.org/10.1177/20499361241241199 |
| spellingShingle | Trung Minh Nguyen Eva Amenta Lynne Chapman Sarvari Yellapragada Bhuvaneswari Krishnan Jonathan Lim Richard J. Hamill Ibrutinib-associated cutaneous mucormycosis due to an species: report of a case and review of the literature Therapeutic Advances in Infectious Disease |
| title | Ibrutinib-associated cutaneous mucormycosis due to an species: report of a case and review of the literature |
| title_full | Ibrutinib-associated cutaneous mucormycosis due to an species: report of a case and review of the literature |
| title_fullStr | Ibrutinib-associated cutaneous mucormycosis due to an species: report of a case and review of the literature |
| title_full_unstemmed | Ibrutinib-associated cutaneous mucormycosis due to an species: report of a case and review of the literature |
| title_short | Ibrutinib-associated cutaneous mucormycosis due to an species: report of a case and review of the literature |
| title_sort | ibrutinib associated cutaneous mucormycosis due to an species report of a case and review of the literature |
| url | https://doi.org/10.1177/20499361241241199 |
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