Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approach

Electrochemotherapy (ECT) is a minimally invasive and safe treatment gaining positive and long-lasting antitumoral results that are receiving the attention of the scientific community. It is a local treatment that combines the use of electroporation and the administration of cytotoxic drugs to induc...

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Main Authors: Schipilliti Francesca Matilde, Onorato Maurizio, Arrivi Giulia, Panebianco Martina, Lerinò Debora, Milano Annalisa, Roberto Michela, Capalbo Carlo, Mazzuca Federica
Format: Article
Language:English
Published: Sciendo 2022-08-01
Series:Radiology and Oncology
Subjects:
Online Access:https://doi.org/10.2478/raon-2022-0022
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author Schipilliti Francesca Matilde
Onorato Maurizio
Arrivi Giulia
Panebianco Martina
Lerinò Debora
Milano Annalisa
Roberto Michela
Capalbo Carlo
Mazzuca Federica
author_facet Schipilliti Francesca Matilde
Onorato Maurizio
Arrivi Giulia
Panebianco Martina
Lerinò Debora
Milano Annalisa
Roberto Michela
Capalbo Carlo
Mazzuca Federica
author_sort Schipilliti Francesca Matilde
collection DOAJ
description Electrochemotherapy (ECT) is a minimally invasive and safe treatment gaining positive and long-lasting antitumoral results that are receiving the attention of the scientific community. It is a local treatment that combines the use of electroporation and the administration of cytotoxic drugs to induce cell death in the target tissue. ECT is largely used for the treatment of cutaneous and subcutaneous lesions, and good results have been reported for the treatment of deep visceral tumors. The latest literature review is provided. Moreover, in line with its development for the treatment of visceral tumors in this article, we describe a novel approach of ECT: endoscopic treatment of colorectal cancer. Endoscopic ECT application was combined with systemic chemotherapy in the treatment of obstructing rectal cancer without prospective surgery. A good response after ECT was described: concentric involvement of the rectum was reduced, and no stenosing lesions were detected.
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spelling doaj.art-4428ab6bd7fb4243b9221080f8d0f0dd2023-04-11T17:19:28ZengSciendoRadiology and Oncology1581-32072022-08-0156328529110.2478/raon-2022-0022Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approachSchipilliti Francesca Matilde0Onorato MaurizioArrivi Giulia1Panebianco Martina2Lerinò Debora3Milano Annalisa4Roberto Michela5Capalbo Carlo6Mazzuca Federica7Oncological Department, Sant’Andrea Hospital, University Sapienza in Rome, Rome, ItalyOncological Department, Sant’Andrea Hospital, University Sapienza in Rome, Rome, ItalyOncological Department, Sant’Andrea Hospital, University Sapienza in Rome, Rome, ItalyOncological Department, Sant’Andrea Hospital, University Sapienza in Rome, Rome, ItalyOncological Department, Sant’Andrea Hospital, University Sapienza in Rome, Rome, ItalyOncological Department, University Sapienza in Rome, Rome, ItalyOncological Department, Sant’Andrea Hospital, University Sapienza in Rome, Rome, ItalyOncological Department, Sant’Andrea Hospital, University Sapienza in Rome, Rome, ItalyElectrochemotherapy (ECT) is a minimally invasive and safe treatment gaining positive and long-lasting antitumoral results that are receiving the attention of the scientific community. It is a local treatment that combines the use of electroporation and the administration of cytotoxic drugs to induce cell death in the target tissue. ECT is largely used for the treatment of cutaneous and subcutaneous lesions, and good results have been reported for the treatment of deep visceral tumors. The latest literature review is provided. Moreover, in line with its development for the treatment of visceral tumors in this article, we describe a novel approach of ECT: endoscopic treatment of colorectal cancer. Endoscopic ECT application was combined with systemic chemotherapy in the treatment of obstructing rectal cancer without prospective surgery. A good response after ECT was described: concentric involvement of the rectum was reduced, and no stenosing lesions were detected.https://doi.org/10.2478/raon-2022-0022electrochemotherapycolorectal cancerendoscopy
spellingShingle Schipilliti Francesca Matilde
Onorato Maurizio
Arrivi Giulia
Panebianco Martina
Lerinò Debora
Milano Annalisa
Roberto Michela
Capalbo Carlo
Mazzuca Federica
Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approach
Radiology and Oncology
electrochemotherapy
colorectal cancer
endoscopy
title Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approach
title_full Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approach
title_fullStr Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approach
title_full_unstemmed Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approach
title_short Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approach
title_sort electrochemotherapy for solid tumors literature review and presentation of a novel endoscopic approach
topic electrochemotherapy
colorectal cancer
endoscopy
url https://doi.org/10.2478/raon-2022-0022
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