Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit

<h4>Purpose</h4> Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess...

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Main Authors: Rafael Ferracini Cabral, Diogo Goulart Corrêa, Nicolle Zimmermann, Gustavo Tukamoto, Tadeu Takao Almodovar Kubo, Rochele Paz Fonseca, Marcos Martins Silva, Nina Ventura Wilner, Paulo Roberto Valle Bahia, Emerson Leandro Gasparetto, Edson Marchiori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664225/?tool=EBI
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author Rafael Ferracini Cabral
Diogo Goulart Corrêa
Nicolle Zimmermann
Gustavo Tukamoto
Tadeu Takao Almodovar Kubo
Rochele Paz Fonseca
Marcos Martins Silva
Nina Ventura Wilner
Paulo Roberto Valle Bahia
Emerson Leandro Gasparetto
Edson Marchiori
author_facet Rafael Ferracini Cabral
Diogo Goulart Corrêa
Nicolle Zimmermann
Gustavo Tukamoto
Tadeu Takao Almodovar Kubo
Rochele Paz Fonseca
Marcos Martins Silva
Nina Ventura Wilner
Paulo Roberto Valle Bahia
Emerson Leandro Gasparetto
Edson Marchiori
author_sort Rafael Ferracini Cabral
collection DOAJ
description <h4>Purpose</h4> Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess whether cortical thickness differs between HIV-infected patients with and without working memory deficit. <h4>Methods</h4> Forty-one adult HIV-infected patients with and without working memory deficit were imaged on a 1.5 T scanner. Working memory deficit was classified by composite Z scores for performance on the Digits and Letter-Number Sequencing subtests of the Wechsler Adult Intelligence Scale (third edition; WAIS-III). Cortical thickness was determined using FreeSurfer software. Differences in mean cortical thickness between groups, corrected for multiple comparisons using Monte-Carlo simulation, were examined using the query design estimate contrast tool of the FreeSurfer software. <h4>Results</h4> Greater cortical thickness in left pars opercularis of the inferior frontal gyrus, and rostral and caudal portions of the left middle frontal gyrus (cluster 1; p = .004), and left superior frontal gyrus (cluster 2; p = .004) was observed in HIV-infected patients with working memory deficit compared with those without such deficit. Negative correlations were found between WAIS-III–based Z scores and cortical thickness in the two clusters (cluster 1: ρ = –0.59; cluster 2: ρ = –0.47). <h4>Conclusion</h4> HIV-infected patients with working memory deficit have regions of greater thickness in the left frontal cortices compared with those without such deficit, which may reflect increased synaptic contacts and/or an inflammatory response related to the damage caused by HIV infection.
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spelling doaj.art-4428d16c2d864d5fabb8cb6fca8203052022-12-21T18:44:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficitRafael Ferracini CabralDiogo Goulart CorrêaNicolle ZimmermannGustavo TukamotoTadeu Takao Almodovar KuboRochele Paz FonsecaMarcos Martins SilvaNina Ventura WilnerPaulo Roberto Valle BahiaEmerson Leandro GasparettoEdson Marchiori<h4>Purpose</h4> Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess whether cortical thickness differs between HIV-infected patients with and without working memory deficit. <h4>Methods</h4> Forty-one adult HIV-infected patients with and without working memory deficit were imaged on a 1.5 T scanner. Working memory deficit was classified by composite Z scores for performance on the Digits and Letter-Number Sequencing subtests of the Wechsler Adult Intelligence Scale (third edition; WAIS-III). Cortical thickness was determined using FreeSurfer software. Differences in mean cortical thickness between groups, corrected for multiple comparisons using Monte-Carlo simulation, were examined using the query design estimate contrast tool of the FreeSurfer software. <h4>Results</h4> Greater cortical thickness in left pars opercularis of the inferior frontal gyrus, and rostral and caudal portions of the left middle frontal gyrus (cluster 1; p = .004), and left superior frontal gyrus (cluster 2; p = .004) was observed in HIV-infected patients with working memory deficit compared with those without such deficit. Negative correlations were found between WAIS-III–based Z scores and cortical thickness in the two clusters (cluster 1: ρ = –0.59; cluster 2: ρ = –0.47). <h4>Conclusion</h4> HIV-infected patients with working memory deficit have regions of greater thickness in the left frontal cortices compared with those without such deficit, which may reflect increased synaptic contacts and/or an inflammatory response related to the damage caused by HIV infection.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664225/?tool=EBI
spellingShingle Rafael Ferracini Cabral
Diogo Goulart Corrêa
Nicolle Zimmermann
Gustavo Tukamoto
Tadeu Takao Almodovar Kubo
Rochele Paz Fonseca
Marcos Martins Silva
Nina Ventura Wilner
Paulo Roberto Valle Bahia
Emerson Leandro Gasparetto
Edson Marchiori
Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit
PLoS ONE
title Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit
title_full Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit
title_fullStr Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit
title_full_unstemmed Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit
title_short Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit
title_sort preliminary comparative study of cortical thickness in hiv infected patients with and without working memory deficit
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664225/?tool=EBI
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