Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

Background/Aims: The linoleic acid derivative DCP-LA selectively activates PKCε and inhibits protein phosphatase 1 (PP1). In the present study, we have newly synthesized phosphatidyl-ethanolamine, -serine, -choline, and -inositol containing DCP-LA at the α and β position (diDCP-LA-PE, -PS, PC, and -...

Full description

Bibliographic Details
Main Authors:	Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Tomoyuki Nishizaki
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2013-04-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Protein phosphatase 2A Protein tyrosine phosphatase 1B DCP-LA-phospholipid Protein kinase C Protein phosphatase 1
Online Access:	http://www.karger.com/Article/FullText/350076

Similar Items

DCP-LA-Phosphatidylinositol and Its Enantiomer Exhibit Different Bioactivities
by: Ayako Tsuchiya, et al.
Published: (2014-01-01)

Free Fatty Acids Inhibit Protein Tyrosine Phosphatase 1B and Activate Akt
by: Eisuke Shibata, et al.
Published: (2013-09-01)

Stearic Acid Serves as a Potent Inhibitor of Protein Tyrosine Phosphatase 1B
by: Ayako Tsuchiya, et al.
Published: (2013-11-01)

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
by: Jun'ichi Kobayashi, et al.
Published: (2006-02-01)

A Polydnavirus <i>Protein Tyrosine Phosphatase</i> Negatively Regulates the Host Phenoloxidase Pathway
by: Hong-Shuai Gao, et al.
Published: (2022-12-01)

PTP1B Inhibition Causes Rac1 Activation by Enhancing Receptor Tyrosine Kinase Signaling
by: Ayako Tsuchiya, et al.
Published: (2014-04-01)

PP1, PP2A and PP2B Interplay in the Regulation of Sperm Motility: Lessons from Protein Phosphatase Inhibitors
by: Ana F. Ferreira, et al.
Published: (2022-12-01)

Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
by: Elisa Beatriz Prestes, et al.
Published: (2012-09-01)

LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain
by: Francisca Cornejo, et al.
Published: (2021-12-01)

Inhibitory potential of polyhydroxylated fullerenes against protein tyrosine phosphatase 1B
by: O. L. Kobzar, et al.
Published: (2015-08-01)

A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis
by: James Adams, et al.
Published: (2021-11-01)

Bacterial Protein Tyrosine Phosphatases as Possible Targets for Antimicrobial Therapies in Response to Antibiotic Resistance
by: Alicja Kuban-Jankowska, et al.
Published: (2022-12-01)

T Cell Protein Tyrosine Phosphatase in Osteoimmunology
by: Ya-nan Wang, et al.
Published: (2021-02-01)

Selecting the appropriate hurdles and endpoints for pentilludin, a novel antiaddiction pharmacotherapeutic targeting the receptor type protein tyrosine phosphatase D
by: George R. Uhl, et al.
Published: (2023-04-01)

The protein tyrosine phosphatase PPH‐7 is required for fertility and embryonic development in C. elegans at elevated temperatures
by: Curdin A. Franziscus, et al.
Published: (2024-03-01)

Involvement of protein tyrosine phosphatases in adipogenesis: New anti-obesity targets?
by: Kwang-Hee Bae
Published: (2012-12-01)

Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line
by: Klover Peter, et al.
Published: (2003-07-01)

The Emerging Role of Protein Phosphatase in Regeneration
by: Meiling Zhang, et al.
Published: (2023-05-01)

PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression
by: Anne Liu, et al.
Published: (2022-07-01)

Protein Tyrosine Phosphatases: Mechanisms in Cancer
by: Vignesh Sivaganesh, et al.
Published: (2021-11-01)

In silico extension on the antidiabetic potential of Euonymus laxiflorus natural compounds onto the inhibitability against protein tyrosine phosphatase 1B
by: Thanh Q. Bui, et al.
Published: (2023-12-01)

Revisiting the roles of VHR/DUSP3 phosphatase in human diseases
by: Lilian Cristina Russo, et al.
Published: (2018-09-01)

Association of protein tyrosine phosphatase 1B gene polymorphism with the effects of weight reduction therapy on bodyweight and glycolipid profiles in obese patients
by: Hajime Yamakage, et al.
Published: (2021-08-01)

Function of Macrophage and Parasite Phosphatases in Leishmaniasis
by: Didier Soulat, et al.
Published: (2017-12-01)

Use of an Anaerobic Chamber Environment for the Assay of Endogenous Cellular Protein-Tyrosine Phosphatase Activities
by: Zhu Li, et al.
Published: (2002-01-01)

Water Extract of Mungbean (<i>Vigna radiata</i> L.) Inhibits Protein Tyrosine Phosphatase-1B in Insulin-Resistant HepG2 Cells
by: Orathai Saeting, et al.
Published: (2021-03-01)

The serine-threonine protein phosphatases that regulate the thiazide-sensitive NaCl cotransporter
by: Héctor Carbajal-Contreras, et al.
Published: (2023-02-01)

Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors
by: Ningbo Qin, et al.
Published: (2018-01-01)

Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review
by: Arata Tomiyama, et al.
Published: (2019-02-01)

Protein phosphorylation : analysis of protein phosphorylation, protein kinases inhibirors and protein phossphatases/
by: Hunter, Tony, et al.
Published: (1991)

Shikonin and Juglone Inhibit <i>Mycobacterium tuberculosis</i> Low-Molecular-Weight Protein Tyrosine Phosphatase a (Mt-PTPa)
by: Abdulhakeem O. Sulyman, et al.
Published: (2023-09-01)

Protein Tyrosine Phosphatases in Neuroblastoma: Emerging Roles as Biomarkers and Therapeutic Targets
by: Caroline E. Nunes-Xavier, et al.
Published: (2021-12-01)

Serine/Threonine Protein Phosphatases 1 and 2A in Lung Endothelial Barrier Regulation
by: Rahul S. Patil, et al.
Published: (2023-06-01)

New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activity
by: Daopeng Tan, et al.
Published: (2023-12-01)

Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine
by: Matthew T.N. Yarnall, et al.
Published: (2022-12-01)

Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
by: Feiling Xie, et al.
Published: (2021-11-01)

Phosphatases Decrease Water and Urea Permeability in Rat Inner Medullary Collecting Ducts
by: Yanhua Wang, et al.
Published: (2023-03-01)

Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.
by: Barr, A, et al.
Published: (2006)

The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma
by: Yide Huang, et al.
Published: (2018-03-01)

Thermophilic PHP Protein Tyrosine Phosphatases (Cap8C and Wzb) from Mesophilic Bacteria
by: Adepeju Aberuagba, et al.
Published: (2024-01-01)