Insights into SARS-CoV-2 Persistence and Its Relevance
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), continues to wreak havoc, threatening the public health services and imposing economic collapse worldwide. Tailoring public health responses to the SARS-CoV-2 pandemic depends on...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/6/1025 |
| _version_ | 1797532113788993536 |
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| author | Belete A. Desimmie Yonas Y. Raru Hesham M. Awadh Peimei He Samson Teka Kara S. Willenburg |
| author_facet | Belete A. Desimmie Yonas Y. Raru Hesham M. Awadh Peimei He Samson Teka Kara S. Willenburg |
| author_sort | Belete A. Desimmie |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), continues to wreak havoc, threatening the public health services and imposing economic collapse worldwide. Tailoring public health responses to the SARS-CoV-2 pandemic depends on understanding the mechanism of viral replication, disease pathogenesis, accurately identifying acute infections, and mapping the spreading risk of hotspots across the globe. However, effective identification and isolation of persons with asymptomatic and mild SARS-CoV-2 infections remain the major obstacles to efforts in controlling the SARS-CoV-2 spread and hence the pandemic. Understanding the mechanism of persistent viral shedding, reinfection, and the post-acute sequalae of SARS-CoV-2 infection (PASC) is crucial in our efforts to combat the pandemic and provide better care and rehabilitation to survivors. Here, we present a living literature review (January 2020 through 15 March 2021) on SARS-CoV-2 viral persistence, reinfection, and PASC. We also highlight potential areas of research to uncover putative links between viral persistence, intra-host evolution, host immune status, and protective immunity to guide and direct future basic science and clinical research priorities. |
| first_indexed | 2024-03-10T10:54:30Z |
| format | Article |
| id | doaj.art-442ae947d29e41a3a9758e51d7abc9ba |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:54:30Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-442ae947d29e41a3a9758e51d7abc9ba2023-11-21T21:59:10ZengMDPI AGViruses1999-49152021-05-01136102510.3390/v13061025Insights into SARS-CoV-2 Persistence and Its RelevanceBelete A. Desimmie0Yonas Y. Raru1Hesham M. Awadh2Peimei He3Samson Teka4Kara S. Willenburg5Department of Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USADepartment of Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USADepartment of Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USADepartment of Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USADepartment of Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USADepartment of Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USASevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), continues to wreak havoc, threatening the public health services and imposing economic collapse worldwide. Tailoring public health responses to the SARS-CoV-2 pandemic depends on understanding the mechanism of viral replication, disease pathogenesis, accurately identifying acute infections, and mapping the spreading risk of hotspots across the globe. However, effective identification and isolation of persons with asymptomatic and mild SARS-CoV-2 infections remain the major obstacles to efforts in controlling the SARS-CoV-2 spread and hence the pandemic. Understanding the mechanism of persistent viral shedding, reinfection, and the post-acute sequalae of SARS-CoV-2 infection (PASC) is crucial in our efforts to combat the pandemic and provide better care and rehabilitation to survivors. Here, we present a living literature review (January 2020 through 15 March 2021) on SARS-CoV-2 viral persistence, reinfection, and PASC. We also highlight potential areas of research to uncover putative links between viral persistence, intra-host evolution, host immune status, and protective immunity to guide and direct future basic science and clinical research priorities.https://www.mdpi.com/1999-4915/13/6/1025coronavirusesSARS-CoV-2COVID-19viral persistencereinfectionlong COVID |
| spellingShingle | Belete A. Desimmie Yonas Y. Raru Hesham M. Awadh Peimei He Samson Teka Kara S. Willenburg Insights into SARS-CoV-2 Persistence and Its Relevance Viruses coronaviruses SARS-CoV-2 COVID-19 viral persistence reinfection long COVID |
| title | Insights into SARS-CoV-2 Persistence and Its Relevance |
| title_full | Insights into SARS-CoV-2 Persistence and Its Relevance |
| title_fullStr | Insights into SARS-CoV-2 Persistence and Its Relevance |
| title_full_unstemmed | Insights into SARS-CoV-2 Persistence and Its Relevance |
| title_short | Insights into SARS-CoV-2 Persistence and Its Relevance |
| title_sort | insights into sars cov 2 persistence and its relevance |
| topic | coronaviruses SARS-CoV-2 COVID-19 viral persistence reinfection long COVID |
| url | https://www.mdpi.com/1999-4915/13/6/1025 |
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