Study on thermostabilizers for trivalent oral poliomyelitis vaccine
Different formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate form...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1990-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300010 |
| _version_ | 1797712595173507072 |
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| author | M. L. F. Leal F. J. C. Lopes M. H. G. Carvalho H. A. B. Moura S. A. F. Soares |
| author_facet | M. L. F. Leal F. J. C. Lopes M. H. G. Carvalho H. A. B. Moura S. A. F. Soares |
| author_sort | M. L. F. Leal |
| collection | DOAJ |
| description | Different formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs. The low corrosive formulation was rejected, due to low thermostability on storage. |
| first_indexed | 2024-03-12T07:24:05Z |
| format | Article |
| id | doaj.art-442b15c8d6244b53ac03f297a16efcdb |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:24:05Z |
| publishDate | 1990-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-442b15c8d6244b53ac03f297a16efcdb2023-09-02T22:14:54ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601990-09-0185332933810.1590/S0074-02761990000300010Study on thermostabilizers for trivalent oral poliomyelitis vaccineM. L. F. LealF. J. C. LopesM. H. G. CarvalhoH. A. B. MouraS. A. F. SoaresDifferent formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs. The low corrosive formulation was rejected, due to low thermostability on storage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300010poliovaccinethermostabilizers |
| spellingShingle | M. L. F. Leal F. J. C. Lopes M. H. G. Carvalho H. A. B. Moura S. A. F. Soares Study on thermostabilizers for trivalent oral poliomyelitis vaccine Memorias do Instituto Oswaldo Cruz poliovaccine thermostabilizers |
| title | Study on thermostabilizers for trivalent oral poliomyelitis vaccine |
| title_full | Study on thermostabilizers for trivalent oral poliomyelitis vaccine |
| title_fullStr | Study on thermostabilizers for trivalent oral poliomyelitis vaccine |
| title_full_unstemmed | Study on thermostabilizers for trivalent oral poliomyelitis vaccine |
| title_short | Study on thermostabilizers for trivalent oral poliomyelitis vaccine |
| title_sort | study on thermostabilizers for trivalent oral poliomyelitis vaccine |
| topic | poliovaccine thermostabilizers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300010 |
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