Prednisolone Suppresses the Extracellular Release of HMGB-1 and Associated Inflammatory Pathways in Kawasaki Disease

Prednisolone Suppresses the Extracellular Release of HMGB-1 and Associated Inflammatory Pathways in Kawasaki Disease

Innate immune activity plays an essential role in the development of Kawasaki disease (KD) vasculitis. Extracellular release of high mobility group box-1 (HMGB-1), an endogenous damage-associated molecular pattern protein that can activate the innate immune system and drive host inflammatory respons...

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Bibliographic Details
Main Authors: Kentaro Ueno, Yuichi Nomura, Yasuko Morita, Yoshifumi Kawano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
pediatrics
Kawasaki disease (KD)
DAMPs (damage-associated molecular patterns)
prednisolone
high mobility group box-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.640315/full

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