Association of mycoplasma pneumoniae and (rs9271366) HLA-DRB1gene polymorphism with the immune susceptibility to rheumatoid arthritis
Background: Rheumatoid arthritis (RA) is a chronic, inflammatory disease that affects the immune system. The primary cause of RA is unknown, but there is evidence that genetic and environmental factors also contribute to the development of the disease. Objectives: This study aimed to illustrate the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Medical Journal of Babylon |
| Subjects: | |
| Online Access: | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=3;spage=511;epage=516;aulast=Obaead |
| _version_ | 1797645422876950528 |
|---|---|
| author | Wael Rasheed Obaead Alfatlawi Mohammed A K Al-Saadi Adil Hasan Ali Akbar |
| author_facet | Wael Rasheed Obaead Alfatlawi Mohammed A K Al-Saadi Adil Hasan Ali Akbar |
| author_sort | Wael Rasheed Obaead Alfatlawi |
| collection | DOAJ |
| description | Background: Rheumatoid arthritis (RA) is a chronic, inflammatory disease that affects the immune system. The primary cause of RA is unknown, but there is evidence that genetic and environmental factors also contribute to the development of the disease. Objectives: This study aimed to illustrate the relationship between the RA and Mycoplasma pneumoniae. Materials and Methods: The work was performed on 50 RA patients of various ages, ranging from 25 to 75 years of age, who were treated at the rheumatology clinic of the city of Medical Marjan between February 2022 to October 2022. Blood samples were used for DNA extraction. HLA-DRB1, IL-6 and mycoplasma were detected by enzyme-linked immunosorbent assay (ELISA). Results: The results showed that compared with RA patients not infected with Mycoplasma pneumoniae and healthy subjects, serum IL-6 concentration was significantly increased in RA patients infected with Mycoplasma pneumoniae. The results showed that serum concentrations of HLADRB1 were significantly elevated in RA patients infected with M. pneumoniae compared with RA patients not infected with M. pneumoniae and healthy subjects. Conclusions: In HLA-DRB1 the SNP rs9271366 was significantly associated with RA and G allele represent as dominant pathogenic allele in which the individual that carry GG and AG genotype have more susceptibility to mycoplasma infection than subjects that carry AA genotype (P = 0.036). |
| first_indexed | 2024-03-11T14:46:08Z |
| format | Article |
| id | doaj.art-442bfcd4013746109ca0ef7ba16cb054 |
| institution | Directory Open Access Journal |
| issn | 1812-156X 2312-6760 |
| language | English |
| last_indexed | 2024-03-11T14:46:08Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj.art-442bfcd4013746109ca0ef7ba16cb0542023-10-30T11:05:10ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602023-01-0120351151610.4103/MJBL.MJBL_191_23Association of mycoplasma pneumoniae and (rs9271366) HLA-DRB1gene polymorphism with the immune susceptibility to rheumatoid arthritisWael Rasheed Obaead AlfatlawiMohammed A K Al-SaadiAdil Hasan Ali AkbarBackground: Rheumatoid arthritis (RA) is a chronic, inflammatory disease that affects the immune system. The primary cause of RA is unknown, but there is evidence that genetic and environmental factors also contribute to the development of the disease. Objectives: This study aimed to illustrate the relationship between the RA and Mycoplasma pneumoniae. Materials and Methods: The work was performed on 50 RA patients of various ages, ranging from 25 to 75 years of age, who were treated at the rheumatology clinic of the city of Medical Marjan between February 2022 to October 2022. Blood samples were used for DNA extraction. HLA-DRB1, IL-6 and mycoplasma were detected by enzyme-linked immunosorbent assay (ELISA). Results: The results showed that compared with RA patients not infected with Mycoplasma pneumoniae and healthy subjects, serum IL-6 concentration was significantly increased in RA patients infected with Mycoplasma pneumoniae. The results showed that serum concentrations of HLADRB1 were significantly elevated in RA patients infected with M. pneumoniae compared with RA patients not infected with M. pneumoniae and healthy subjects. Conclusions: In HLA-DRB1 the SNP rs9271366 was significantly associated with RA and G allele represent as dominant pathogenic allele in which the individual that carry GG and AG genotype have more susceptibility to mycoplasma infection than subjects that carry AA genotype (P = 0.036).http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=3;spage=511;epage=516;aulast=Obaeadhla-rb1il-6mycoplasmarheumatoid arthritis |
| spellingShingle | Wael Rasheed Obaead Alfatlawi Mohammed A K Al-Saadi Adil Hasan Ali Akbar Association of mycoplasma pneumoniae and (rs9271366) HLA-DRB1gene polymorphism with the immune susceptibility to rheumatoid arthritis Medical Journal of Babylon hla-rb1 il-6 mycoplasma rheumatoid arthritis |
| title | Association of mycoplasma pneumoniae and (rs9271366) HLA-DRB1gene polymorphism with the immune susceptibility to rheumatoid arthritis |
| title_full | Association of mycoplasma pneumoniae and (rs9271366) HLA-DRB1gene polymorphism with the immune susceptibility to rheumatoid arthritis |
| title_fullStr | Association of mycoplasma pneumoniae and (rs9271366) HLA-DRB1gene polymorphism with the immune susceptibility to rheumatoid arthritis |
| title_full_unstemmed | Association of mycoplasma pneumoniae and (rs9271366) HLA-DRB1gene polymorphism with the immune susceptibility to rheumatoid arthritis |
| title_short | Association of mycoplasma pneumoniae and (rs9271366) HLA-DRB1gene polymorphism with the immune susceptibility to rheumatoid arthritis |
| title_sort | association of mycoplasma pneumoniae and rs9271366 hla drb1gene polymorphism with the immune susceptibility to rheumatoid arthritis |
| topic | hla-rb1 il-6 mycoplasma rheumatoid arthritis |
| url | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=3;spage=511;epage=516;aulast=Obaead |
| work_keys_str_mv | AT waelrasheedobaeadalfatlawi associationofmycoplasmapneumoniaeandrs9271366hladrb1genepolymorphismwiththeimmunesusceptibilitytorheumatoidarthritis AT mohammedakalsaadi associationofmycoplasmapneumoniaeandrs9271366hladrb1genepolymorphismwiththeimmunesusceptibilitytorheumatoidarthritis AT adilhasanaliakbar associationofmycoplasmapneumoniaeandrs9271366hladrb1genepolymorphismwiththeimmunesusceptibilitytorheumatoidarthritis |