Bacterial Profile and Antibiotic Resistance among Cancer Patients with Urinary Tract Infection in a National Tertiary Cancer Hospital of Nepal
Cancer patients are at high risk of antibiotic resistant bacterial urinary tract infections (UTIs). In this study, we assessed the bacterial profile and antibiotic resistance among cancer patients suspected of UTI in B.P. Koirala Memorial Cancer Hospital in Nepal through a cross-sectional study with...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/6/2/49 |
| _version_ | 1827695192205950976 |
|---|---|
| author | Gambhir Shrestha Xiaolin Wei Katrina Hann Kyaw Thu Soe Srinath Satyanarayana Bhola Siwakoti Shankar Bastakoti Rashmi Mulmi Kritika Rana Nirmal Lamichhane |
| author_facet | Gambhir Shrestha Xiaolin Wei Katrina Hann Kyaw Thu Soe Srinath Satyanarayana Bhola Siwakoti Shankar Bastakoti Rashmi Mulmi Kritika Rana Nirmal Lamichhane |
| author_sort | Gambhir Shrestha |
| collection | DOAJ |
| description | Cancer patients are at high risk of antibiotic resistant bacterial urinary tract infections (UTIs). In this study, we assessed the bacterial profile and antibiotic resistance among cancer patients suspected of UTI in B.P. Koirala Memorial Cancer Hospital in Nepal through a cross-sectional study with routinely collected data. All cancer patients who had a recorded urine culture between July 2018–June 2019 were included in the study. Out of 308 patients who had undergone culture, 73 (24%) of samples had bacterial growth. The most common organisms isolated were <i>E. coli</i> (58%), <i>Staphylococcus</i> (11%) and <i>Klebsiella</i> (10%). These bacteria had undergone susceptibility testing to 27 different antibiotics in various proportions. Of the limited antibiotic testing levels, nitrofurantoin (54/66, 82%) and amikacin (30/51, 59%) were the most common. Among those tested, there were high levels of resistance to antibiotics in the “Access” and “Watch” groups of antibiotics (2019 WHO classification). In the “Reserve” group, both antibiotics showed resistance (polymyxin 15%, tigecycline 8%). Multidrug resistance was seen among 89% of the positive culture samples. This calls for urgent measures to optimize the use of antibiotics in UTI care at policy and health facility levels through stewardship to prevent further augmentation of antibiotic resistance among cancer patients. |
| first_indexed | 2024-03-10T12:21:04Z |
| format | Article |
| id | doaj.art-442e6d2bbda5466087dfa679618509e2 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T12:21:04Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-442e6d2bbda5466087dfa679618509e22023-11-21T15:28:31ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-04-01624910.3390/tropicalmed6020049Bacterial Profile and Antibiotic Resistance among Cancer Patients with Urinary Tract Infection in a National Tertiary Cancer Hospital of NepalGambhir Shrestha0Xiaolin Wei1Katrina Hann2Kyaw Thu Soe3Srinath Satyanarayana4Bhola Siwakoti5Shankar Bastakoti6Rashmi Mulmi7Kritika Rana8Nirmal Lamichhane9Department of Community Medicine, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu 44600, NepalDalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, CanadaSustainable Health Systems, Freetown 42215, Sierra LeoneDepartment of Medical Research (Pyin Oo Lwin Branch), Ministry of Health and Sports, Nay Pyi Taw 15011, MyanmarCenter for Operational Research, International Union against Tuberculosis and Lung Disease, 75000 Paris, FranceDepartment of Cancer Prevention, Control and Research, B.P. Koirala Memorial Cancer Hospital, Chitwan 44200, NepalDepartment of Pathology, B.P. Koirala Memorial Cancer Hospital, Chitwan 44200, NepalWorld Health Organization, Kathmandu 44600, NepalWorld Health Organization, Kathmandu 44600, NepalDepartment of Surgical Oncology, B.P. Koirala Memorial Cancer Hospital, Chitwan 44200, NepalCancer patients are at high risk of antibiotic resistant bacterial urinary tract infections (UTIs). In this study, we assessed the bacterial profile and antibiotic resistance among cancer patients suspected of UTI in B.P. Koirala Memorial Cancer Hospital in Nepal through a cross-sectional study with routinely collected data. All cancer patients who had a recorded urine culture between July 2018–June 2019 were included in the study. Out of 308 patients who had undergone culture, 73 (24%) of samples had bacterial growth. The most common organisms isolated were <i>E. coli</i> (58%), <i>Staphylococcus</i> (11%) and <i>Klebsiella</i> (10%). These bacteria had undergone susceptibility testing to 27 different antibiotics in various proportions. Of the limited antibiotic testing levels, nitrofurantoin (54/66, 82%) and amikacin (30/51, 59%) were the most common. Among those tested, there were high levels of resistance to antibiotics in the “Access” and “Watch” groups of antibiotics (2019 WHO classification). In the “Reserve” group, both antibiotics showed resistance (polymyxin 15%, tigecycline 8%). Multidrug resistance was seen among 89% of the positive culture samples. This calls for urgent measures to optimize the use of antibiotics in UTI care at policy and health facility levels through stewardship to prevent further augmentation of antibiotic resistance among cancer patients.https://www.mdpi.com/2414-6366/6/2/49neoplasmsurinary tract infectionsantimicrobial resistance surveillanceoncologyoperational researchSORT-IT |
| spellingShingle | Gambhir Shrestha Xiaolin Wei Katrina Hann Kyaw Thu Soe Srinath Satyanarayana Bhola Siwakoti Shankar Bastakoti Rashmi Mulmi Kritika Rana Nirmal Lamichhane Bacterial Profile and Antibiotic Resistance among Cancer Patients with Urinary Tract Infection in a National Tertiary Cancer Hospital of Nepal Tropical Medicine and Infectious Disease neoplasms urinary tract infections antimicrobial resistance surveillance oncology operational research SORT-IT |
| title | Bacterial Profile and Antibiotic Resistance among Cancer Patients with Urinary Tract Infection in a National Tertiary Cancer Hospital of Nepal |
| title_full | Bacterial Profile and Antibiotic Resistance among Cancer Patients with Urinary Tract Infection in a National Tertiary Cancer Hospital of Nepal |
| title_fullStr | Bacterial Profile and Antibiotic Resistance among Cancer Patients with Urinary Tract Infection in a National Tertiary Cancer Hospital of Nepal |
| title_full_unstemmed | Bacterial Profile and Antibiotic Resistance among Cancer Patients with Urinary Tract Infection in a National Tertiary Cancer Hospital of Nepal |
| title_short | Bacterial Profile and Antibiotic Resistance among Cancer Patients with Urinary Tract Infection in a National Tertiary Cancer Hospital of Nepal |
| title_sort | bacterial profile and antibiotic resistance among cancer patients with urinary tract infection in a national tertiary cancer hospital of nepal |
| topic | neoplasms urinary tract infections antimicrobial resistance surveillance oncology operational research SORT-IT |
| url | https://www.mdpi.com/2414-6366/6/2/49 |
| work_keys_str_mv | AT gambhirshrestha bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT xiaolinwei bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT katrinahann bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT kyawthusoe bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT srinathsatyanarayana bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT bholasiwakoti bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT shankarbastakoti bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT rashmimulmi bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT kritikarana bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal AT nirmallamichhane bacterialprofileandantibioticresistanceamongcancerpatientswithurinarytractinfectioninanationaltertiarycancerhospitalofnepal |