Effects of Red Blood Cell Transfusions on Distant Metastases of Oral Squamous Cell Carcinomas
There is no consensus on the effect of red blood cell (RBC) transfusions on patients with oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the association between RBC administration and the occurrence of distant metastases (M+) after surgical treatment of OSCC. All medic...
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/1/138 |
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| author | Leonard Simon Brandenburg Marc Christian Metzger Philipp Poxleitner Pit Jacob Voss Kirstin Vach Johannes Hell Konstantin Hasel Julia Vera Weingart Steffen Jochen Schwarz Michael Andreas Ermer |
| author_facet | Leonard Simon Brandenburg Marc Christian Metzger Philipp Poxleitner Pit Jacob Voss Kirstin Vach Johannes Hell Konstantin Hasel Julia Vera Weingart Steffen Jochen Schwarz Michael Andreas Ermer |
| author_sort | Leonard Simon Brandenburg |
| collection | DOAJ |
| description | There is no consensus on the effect of red blood cell (RBC) transfusions on patients with oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the association between RBC administration and the occurrence of distant metastases (M+) after surgical treatment of OSCC. All medical records of patients who underwent primary surgery for OSCC in our department (2003–2019) were analyzed retrospectively (<i>n</i> = 609). Chi and Cox regression models were used to analyze the influence of transfusion on the development of M+, and survival rates. Kaplan–Meier curves were used for graphical presentation. A multitude of patient-specific factors showed a statistical impact in univariate analysis (transfusion, age, gender, diabetes, pT, pN, L, V, Pn, G, UICC, adjuvant therapy, free microvascular transplant, preoperative hemoglobin level). Transfusion status and pN stage were the only variables that showed a significant correlation to M+ in the multivariate Cox model. The hazard ratios for the occurrence of M+ were 2.42 for RBC transfusions and 2.99 for pN+. Administration of RBC transfusions was identified as a significant prognostic parameter for the occurrence of distant metastases after surgical treatment of OSCC. Hence, the administration of RBC transfusions should be considered carefully in the perioperative management. |
| first_indexed | 2024-03-10T03:47:11Z |
| format | Article |
| id | doaj.art-442f16414bd248729925387ca05a77ab |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:47:11Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-442f16414bd248729925387ca05a77ab2023-11-23T11:16:40ZengMDPI AGCancers2072-66942021-12-0114113810.3390/cancers14010138Effects of Red Blood Cell Transfusions on Distant Metastases of Oral Squamous Cell CarcinomasLeonard Simon Brandenburg0Marc Christian Metzger1Philipp Poxleitner2Pit Jacob Voss3Kirstin Vach4Johannes Hell5Konstantin Hasel6Julia Vera Weingart7Steffen Jochen Schwarz8Michael Andreas Ermer9Department of Oral and Maxillofacial Surgery, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyDepartment of Oral and Maxillofacial Surgery, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyDepartment of Oral and Maxillofacial Surgery, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyDepartment of Oral and Maxillofacial Surgery, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Zinkmattenstr. 6A, 79108 Freiburg, GermanyDepartment of Anesthesiology and Critical Care, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyDepartment of Oral and Maxillofacial Surgery, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyDepartment of Oral and Maxillofacial Surgery, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyDepartment of Oral and Maxillofacial Surgery, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyDepartment of Oral and Maxillofacial Surgery, Clinic, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, GermanyThere is no consensus on the effect of red blood cell (RBC) transfusions on patients with oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the association between RBC administration and the occurrence of distant metastases (M+) after surgical treatment of OSCC. All medical records of patients who underwent primary surgery for OSCC in our department (2003–2019) were analyzed retrospectively (<i>n</i> = 609). Chi and Cox regression models were used to analyze the influence of transfusion on the development of M+, and survival rates. Kaplan–Meier curves were used for graphical presentation. A multitude of patient-specific factors showed a statistical impact in univariate analysis (transfusion, age, gender, diabetes, pT, pN, L, V, Pn, G, UICC, adjuvant therapy, free microvascular transplant, preoperative hemoglobin level). Transfusion status and pN stage were the only variables that showed a significant correlation to M+ in the multivariate Cox model. The hazard ratios for the occurrence of M+ were 2.42 for RBC transfusions and 2.99 for pN+. Administration of RBC transfusions was identified as a significant prognostic parameter for the occurrence of distant metastases after surgical treatment of OSCC. Hence, the administration of RBC transfusions should be considered carefully in the perioperative management.https://www.mdpi.com/2072-6694/14/1/138red blood cell transfusionoral squamous cell carcinomadistant metastasisrisk factor |
| spellingShingle | Leonard Simon Brandenburg Marc Christian Metzger Philipp Poxleitner Pit Jacob Voss Kirstin Vach Johannes Hell Konstantin Hasel Julia Vera Weingart Steffen Jochen Schwarz Michael Andreas Ermer Effects of Red Blood Cell Transfusions on Distant Metastases of Oral Squamous Cell Carcinomas Cancers red blood cell transfusion oral squamous cell carcinoma distant metastasis risk factor |
| title | Effects of Red Blood Cell Transfusions on Distant Metastases of Oral Squamous Cell Carcinomas |
| title_full | Effects of Red Blood Cell Transfusions on Distant Metastases of Oral Squamous Cell Carcinomas |
| title_fullStr | Effects of Red Blood Cell Transfusions on Distant Metastases of Oral Squamous Cell Carcinomas |
| title_full_unstemmed | Effects of Red Blood Cell Transfusions on Distant Metastases of Oral Squamous Cell Carcinomas |
| title_short | Effects of Red Blood Cell Transfusions on Distant Metastases of Oral Squamous Cell Carcinomas |
| title_sort | effects of red blood cell transfusions on distant metastases of oral squamous cell carcinomas |
| topic | red blood cell transfusion oral squamous cell carcinoma distant metastasis risk factor |
| url | https://www.mdpi.com/2072-6694/14/1/138 |
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