Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

BackgroundProtective immunity against intestinal helminths requires induction of robust type-2 immunity orchestrated by various cellular and soluble effectors which promote goblet cell hyperplasia, mucus production, epithelial proliferation, and smooth muscle contractions to expel worms and re-estab...

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Bibliographic Details
Main Authors: Ioanna Petta, Marie Thorp, Maarten Ciers, Gillian Blancke, Louis Boon, Tim Meese, Filip Van Nieuwerburgh, Andy Wullaert, Richard Grencis, Dirk Elewaut, Geert van Loo, Lars Vereecke
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
immunity to parasites
helminth infection
innate immunity
adaptive immunity
type-2 response
macrophage polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1373745/full

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