Allergy vaccines for specific immunotherapy
Allergen-specific immunotherapy (ASIT) has been used for more than a hundred years to treat patients with IgEmediated allergic diseases. The most common allergens have been obtained using molecular cloning technology in the past two decades. To increase the safety of immunotherapy, a large group of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2021-03-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.elpub.ru/jour/article/view/993 |
| _version_ | 1818081537332084736 |
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| author | S. Yu. Petrova S. V. Khlgatian V. M. Berzhets A. V. Vasileva |
| author_facet | S. Yu. Petrova S. V. Khlgatian V. M. Berzhets A. V. Vasileva |
| author_sort | S. Yu. Petrova |
| collection | DOAJ |
| description | Allergen-specific immunotherapy (ASIT) has been used for more than a hundred years to treat patients with IgEmediated allergic diseases. The most common allergens have been obtained using molecular cloning technology in the past two decades. To increase the safety of immunotherapy, a large group of genetically modified allergens with reduced allergenic activity was created. The mechanism of action of these therapeutic allergens differs from natural allergen extracts, and more research is needed to understand how desensitization occurs in each case. The objective of this review is to introduce readers to new therapeutic allergy vaccines and their structural modification features as well as immunological effects on the body. To achieve this objective, we have analyzed and systematized the experimental developments presented in the literature on the main directions of creating new allergy vaccines: hypoallergenic derivatives of recombinant allergens, T cell epitope-based allergy vaccines and B cell epitope-based allergy vaccines, DNA vaccines.Summing up the results of the research presented in the literature, it is necessary to note the high heterogeneity of designs used to achieve the high efficiency of the developed therapeutic allergens. All allergy vaccines presented in the review solve the tasks set by the researchers: in experimental animal models they induce immunogenicity or tolerance, in clinical trials they reduce the symptoms of allergic reactions. The the effectiveness of the proposed medicinal products is quite high but its evaluation requires further long-term preclinical and clinical trials to confirm the safety and harmlessness of the created allergy vaccines. |
| first_indexed | 2024-12-10T19:07:47Z |
| format | Article |
| id | doaj.art-4430fb42512f410fb8bb832502fd2550 |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-12-10T19:07:47Z |
| publishDate | 2021-03-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-4430fb42512f410fb8bb832502fd25502022-12-22T01:36:51ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132021-03-0198110411210.36233/0372-9311-11712Allergy vaccines for specific immunotherapyS. Yu. Petrova0S. V. Khlgatian1V. M. Berzhets2A. V. Vasileva3I. Mechnikov Research Institute of Vaccines and SeraI. Mechnikov Research Institute of Vaccines and SeraI. Mechnikov Research Institute of Vaccines and SeraI. Mechnikov Research Institute of Vaccines and SeraAllergen-specific immunotherapy (ASIT) has been used for more than a hundred years to treat patients with IgEmediated allergic diseases. The most common allergens have been obtained using molecular cloning technology in the past two decades. To increase the safety of immunotherapy, a large group of genetically modified allergens with reduced allergenic activity was created. The mechanism of action of these therapeutic allergens differs from natural allergen extracts, and more research is needed to understand how desensitization occurs in each case. The objective of this review is to introduce readers to new therapeutic allergy vaccines and their structural modification features as well as immunological effects on the body. To achieve this objective, we have analyzed and systematized the experimental developments presented in the literature on the main directions of creating new allergy vaccines: hypoallergenic derivatives of recombinant allergens, T cell epitope-based allergy vaccines and B cell epitope-based allergy vaccines, DNA vaccines.Summing up the results of the research presented in the literature, it is necessary to note the high heterogeneity of designs used to achieve the high efficiency of the developed therapeutic allergens. All allergy vaccines presented in the review solve the tasks set by the researchers: in experimental animal models they induce immunogenicity or tolerance, in clinical trials they reduce the symptoms of allergic reactions. The the effectiveness of the proposed medicinal products is quite high but its evaluation requires further long-term preclinical and clinical trials to confirm the safety and harmlessness of the created allergy vaccines.https://microbiol.elpub.ru/jour/article/view/993reviewallergensallergen-specific immunotherapyhypoallergenic derivatives of recombinant allergenst cell-epitope based allergy vaccinesb cell-epitope based allergy vaccinesencapsulated allergensdna vaccines |
| spellingShingle | S. Yu. Petrova S. V. Khlgatian V. M. Berzhets A. V. Vasileva Allergy vaccines for specific immunotherapy Журнал микробиологии, эпидемиологии и иммунобиологии review allergens allergen-specific immunotherapy hypoallergenic derivatives of recombinant allergens t cell-epitope based allergy vaccines b cell-epitope based allergy vaccines encapsulated allergens dna vaccines |
| title | Allergy vaccines for specific immunotherapy |
| title_full | Allergy vaccines for specific immunotherapy |
| title_fullStr | Allergy vaccines for specific immunotherapy |
| title_full_unstemmed | Allergy vaccines for specific immunotherapy |
| title_short | Allergy vaccines for specific immunotherapy |
| title_sort | allergy vaccines for specific immunotherapy |
| topic | review allergens allergen-specific immunotherapy hypoallergenic derivatives of recombinant allergens t cell-epitope based allergy vaccines b cell-epitope based allergy vaccines encapsulated allergens dna vaccines |
| url | https://microbiol.elpub.ru/jour/article/view/993 |
| work_keys_str_mv | AT syupetrova allergyvaccinesforspecificimmunotherapy AT svkhlgatian allergyvaccinesforspecificimmunotherapy AT vmberzhets allergyvaccinesforspecificimmunotherapy AT avvasileva allergyvaccinesforspecificimmunotherapy |