An Overview on ERAP Roles in Infectious Diseases
Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are crucial enzymes shaping the major histocompatibility complex I (MHC I) immunopeptidome. In the ER, these enzymes cooperate in trimming the N-terminal residues from precursors peptides, so as to generate optimal-length antigens to...
Main Authors: | Irma Saulle, Chiara Vicentini, Mario Clerici, Mara Biasin |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/3/720 |
Similar Items
-
A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?
by: Irma Saulle, et al.
Published: (2020-08-01) -
Expression and role of ERAP1 in placental tissues of preeclampsia
by: Yanyan Xu, et al.
Published: (2020-04-01) -
ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?
by: Silvia D’Amico, et al.
Published: (2021-02-01) -
ERAP/HLA-C and KIR Genetic Profile in Couples with Recurrent Implantation Failure
by: Karolina Piekarska, et al.
Published: (2022-10-01) -
A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation
by: Benedetta Mattorre, et al.
Published: (2022-04-01)