Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique
Introduction: Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by a solid dispersion technique. Methods: Solid d...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2011-06-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://apb.tbzmed.ac.ir/Portals/0/Archive/Vol1No1/7-Zaker-Milani.pdf |
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| author | Parvin Zakeri-Milani Somayeh Hallaj Nezhadi Mohammad Barzegar-Jalali Leila Mohammadi Ali Nokhodchi Hadi Valizadeh |
| author_facet | Parvin Zakeri-Milani Somayeh Hallaj Nezhadi Mohammad Barzegar-Jalali Leila Mohammadi Ali Nokhodchi Hadi Valizadeh |
| author_sort | Parvin Zakeri-Milani |
| collection | DOAJ |
| description | Introduction: Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by a solid dispersion technique. Methods: Solid dispersion of prednisolone was prepared with PEG 6000 or different carbohydrates such as lactose and dextrin with various ratios of the drug to carrier i.e., 1:10, 1:20 and 1:40. Solid dispersions were prepared by coevaporation method. The evaluation of the properties of the dispersions was performed using dissolution studies, Fourier-transform infrared spectroscopy and x-ray powder diffractometery. Results: The results indicated that lactose is suitable carriers to enhance the in vitro dissolution rate of prednisolone. The data from the x-ray diffraction showed that the drug was still detectable in its solid state in all solid dispersions except solid dispersions prepared by dextrin as carrier. The results from infrared spectroscopy showed no well-defined drug–carrier interactions for coevaporates. Conclusion: Solid dispersion of a poorly water-soluble drug, prednisolone may alleviate the problems of delayed and inconsistent rate of dissolution of the drug. |
| first_indexed | 2024-12-12T11:44:29Z |
| format | Article |
| id | doaj.art-443159299fc4410698b2166afb4dfd77 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-12T11:44:29Z |
| publishDate | 2011-06-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-443159299fc4410698b2166afb4dfd772022-12-22T00:25:27ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082011-06-01114853Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion TechniqueParvin Zakeri-MilaniSomayeh Hallaj NezhadiMohammad Barzegar-JalaliLeila MohammadiAli NokhodchiHadi ValizadehIntroduction: Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by a solid dispersion technique. Methods: Solid dispersion of prednisolone was prepared with PEG 6000 or different carbohydrates such as lactose and dextrin with various ratios of the drug to carrier i.e., 1:10, 1:20 and 1:40. Solid dispersions were prepared by coevaporation method. The evaluation of the properties of the dispersions was performed using dissolution studies, Fourier-transform infrared spectroscopy and x-ray powder diffractometery. Results: The results indicated that lactose is suitable carriers to enhance the in vitro dissolution rate of prednisolone. The data from the x-ray diffraction showed that the drug was still detectable in its solid state in all solid dispersions except solid dispersions prepared by dextrin as carrier. The results from infrared spectroscopy showed no well-defined drug–carrier interactions for coevaporates. Conclusion: Solid dispersion of a poorly water-soluble drug, prednisolone may alleviate the problems of delayed and inconsistent rate of dissolution of the drug.http://apb.tbzmed.ac.ir/Portals/0/Archive/Vol1No1/7-Zaker-Milani.pdfPrednisoloneSolid dispersionCoevaporateX-ray diffractionFT-IR spectroscopyDissolution |
| spellingShingle | Parvin Zakeri-Milani Somayeh Hallaj Nezhadi Mohammad Barzegar-Jalali Leila Mohammadi Ali Nokhodchi Hadi Valizadeh Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique Advanced Pharmaceutical Bulletin Prednisolone Solid dispersion Coevaporate X-ray diffraction FT-IR spectroscopy Dissolution |
| title | Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique |
| title_full | Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique |
| title_fullStr | Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique |
| title_full_unstemmed | Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique |
| title_short | Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique |
| title_sort | studies on dissolution enhancement of prednisolone a poorly water soluble drug by solid dispersion technique |
| topic | Prednisolone Solid dispersion Coevaporate X-ray diffraction FT-IR spectroscopy Dissolution |
| url | http://apb.tbzmed.ac.ir/Portals/0/Archive/Vol1No1/7-Zaker-Milani.pdf |
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