Recombinant human plasma gelsolin reverses increased permeability of the blood–brain barrier induced by the spike protein of the SARS-CoV-2 virus

Recombinant human plasma gelsolin reverses increased permeability of the blood–brain barrier induced by the spike protein of the SARS-CoV-2 virus

Abstract Background Plasma gelsolin (pGSN) is an important part of the blood actin buffer that prevents negative consequences of possible F-actin deposition in the microcirculation and has various functions during host immune response. Recent reports reveal that severe COVID-19 correlates with reduc...

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Bibliographic Details
Main Authors: Łukasz Suprewicz, Kiet A. Tran, Ewelina Piktel, Krzysztof Fiedoruk, Paul A. Janmey, Peter A. Galie, Robert Bucki
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Neuroinflammation
Subjects:
Plasma gelsolin (pGSN)
COVID-19
SARS-CoV-2
Blood–brain barrier
Microfluidics
Tissue engineering
Online Access:https://doi.org/10.1186/s12974-022-02642-4

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