Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes
Abstract Purpose To evaluate the clinical outcome of subretinal autologous internal limiting membrane (ILM) transplantation during pars-plana vitrectomy for persistent full-thickness macular hole (FTMH) repair. Methods Retrospective, consecutive case series of 13 eyes (13 patients) undergoing small-...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | International Journal of Retina and Vitreous |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40942-023-00524-2 |
| _version_ | 1797349772178227200 |
|---|---|
| author | Hanna Camenzind-Zuche Lucas Janeschitz-Kriegl Pascal W. Hasler Christian Prünte |
| author_facet | Hanna Camenzind-Zuche Lucas Janeschitz-Kriegl Pascal W. Hasler Christian Prünte |
| author_sort | Hanna Camenzind-Zuche |
| collection | DOAJ |
| description | Abstract Purpose To evaluate the clinical outcome of subretinal autologous internal limiting membrane (ILM) transplantation during pars-plana vitrectomy for persistent full-thickness macular hole (FTMH) repair. Methods Retrospective, consecutive case series of 13 eyes (13 patients) undergoing small-incision vitrectomy with ILM transplantation and air tamponade for large persistent FTMH after prior unsuccessful vitrectomy with posterior hyaloid detachment and ILM peeling. Main outcome measurements For all eyes, high-definition spectral domain optical coherence tomography scans (SD-OCT Spectralis, Heidelberg Engineering GmbH, Germany) of the macula were routinely performed before surgery, 1 and 4 weeks after surgery, and at the final follow-up visit. Additionally, age, gender, axial length, macular hole diameter, biomicroscopic fundus evaluation and best‐corrected visual acuity (BCVA) at baseline, 1 and 4 weeks after surgery, and at the final follow-up visit were analyzed. Results Anatomic closure was achieved in all 13 cases (100% success rate). Closure pattern was classified in accordance with to Rossi et al. (Graefe’s Arch Clin Exp Ophthalmol 258(12):2629–2638, 2020). Mean baseline BCVA logMAR was 0.93, mean postoperative BCVA logMAR was 0.66 with a mean postoperative follow-up period of 11.4 months. No re-opening occurred during the observation period. Conclusions Placing an autologous ILM-transplant in the subretinal space beneath the margin of the FTMH can support anatomic restauration and functional improvement in large, persistent FTMHs. |
| first_indexed | 2024-03-08T12:35:16Z |
| format | Article |
| id | doaj.art-443289cde5404b18848e071206e5babe |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-03-08T12:35:16Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-443289cde5404b18848e071206e5babe2024-01-21T12:29:43ZengBMCInternational Journal of Retina and Vitreous2056-99202024-01-011011710.1186/s40942-023-00524-2Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holesHanna Camenzind-Zuche0Lucas Janeschitz-Kriegl1Pascal W. Hasler2Christian Prünte3Department of Ophthalmology, University Hospital Basel, University of BaselDepartment of Ophthalmology, University Hospital Basel, University of BaselDepartment of Ophthalmology, University Hospital Basel, University of BaselDepartment of Ophthalmology, University Hospital Basel, University of BaselAbstract Purpose To evaluate the clinical outcome of subretinal autologous internal limiting membrane (ILM) transplantation during pars-plana vitrectomy for persistent full-thickness macular hole (FTMH) repair. Methods Retrospective, consecutive case series of 13 eyes (13 patients) undergoing small-incision vitrectomy with ILM transplantation and air tamponade for large persistent FTMH after prior unsuccessful vitrectomy with posterior hyaloid detachment and ILM peeling. Main outcome measurements For all eyes, high-definition spectral domain optical coherence tomography scans (SD-OCT Spectralis, Heidelberg Engineering GmbH, Germany) of the macula were routinely performed before surgery, 1 and 4 weeks after surgery, and at the final follow-up visit. Additionally, age, gender, axial length, macular hole diameter, biomicroscopic fundus evaluation and best‐corrected visual acuity (BCVA) at baseline, 1 and 4 weeks after surgery, and at the final follow-up visit were analyzed. Results Anatomic closure was achieved in all 13 cases (100% success rate). Closure pattern was classified in accordance with to Rossi et al. (Graefe’s Arch Clin Exp Ophthalmol 258(12):2629–2638, 2020). Mean baseline BCVA logMAR was 0.93, mean postoperative BCVA logMAR was 0.66 with a mean postoperative follow-up period of 11.4 months. No re-opening occurred during the observation period. Conclusions Placing an autologous ILM-transplant in the subretinal space beneath the margin of the FTMH can support anatomic restauration and functional improvement in large, persistent FTMHs.https://doi.org/10.1186/s40942-023-00524-2Persistent full-thickness macular holeSmall-incision vitrectomyInternal limiting membrane transplantation |
| spellingShingle | Hanna Camenzind-Zuche Lucas Janeschitz-Kriegl Pascal W. Hasler Christian Prünte Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes International Journal of Retina and Vitreous Persistent full-thickness macular hole Small-incision vitrectomy Internal limiting membrane transplantation |
| title | Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes |
| title_full | Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes |
| title_fullStr | Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes |
| title_full_unstemmed | Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes |
| title_short | Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes |
| title_sort | autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large persistent macular holes |
| topic | Persistent full-thickness macular hole Small-incision vitrectomy Internal limiting membrane transplantation |
| url | https://doi.org/10.1186/s40942-023-00524-2 |
| work_keys_str_mv | AT hannacamenzindzuche autologousinternallimitingmembranetransplantationachievesanatomicclosureandfunctionalimprovementinthetreatmentoflargepersistentmacularholes AT lucasjaneschitzkriegl autologousinternallimitingmembranetransplantationachievesanatomicclosureandfunctionalimprovementinthetreatmentoflargepersistentmacularholes AT pascalwhasler autologousinternallimitingmembranetransplantationachievesanatomicclosureandfunctionalimprovementinthetreatmentoflargepersistentmacularholes AT christianprunte autologousinternallimitingmembranetransplantationachievesanatomicclosureandfunctionalimprovementinthetreatmentoflargepersistentmacularholes |