Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects
Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity. These factors significantly limit clinical applications. Due...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/2/336 |
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| author | Vladislav S. Rybchenko Teimur K. Aliev Anna A. Panina Mikhail P. Kirpichnikov Dmitry A. Dolgikh |
| author_facet | Vladislav S. Rybchenko Teimur K. Aliev Anna A. Panina Mikhail P. Kirpichnikov Dmitry A. Dolgikh |
| author_sort | Vladislav S. Rybchenko |
| collection | DOAJ |
| description | Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity. These factors significantly limit clinical applications. Due to their high specificity and affinity, tumor-specific monoclonal antibodies or their antigen-binding fragments are capable of delivering fused cytokines to tumors and, therefore, of decreasing the number and severity of side effects, as well as of enhancing the therapeutic index. The present review surveys the actual antibody–cytokine fusion protein (immunocytokine) formats, their targets, mechanisms of action, and anti-tumor and other biological effects. Special attention is paid to the formats designed to prevent the off-target cytokine–receptor interactions, potentially inducing side effects. Here, we describe preclinical and clinical data and the efficacy of the antibody-mediated cytokine delivery approach, either as a single therapy or in combination with other agents. |
| first_indexed | 2024-03-11T08:17:47Z |
| format | Article |
| id | doaj.art-443434457f5248beb05112bd90eafc28 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T08:17:47Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-443434457f5248beb05112bd90eafc282023-11-16T22:38:33ZengMDPI AGPharmaceutics1999-49232023-01-0115233610.3390/pharmaceutics15020336Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological EffectsVladislav S. Rybchenko0Teimur K. Aliev1Anna A. Panina2Mikhail P. Kirpichnikov3Dmitry A. Dolgikh4Bioengineering Department, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, RussiaBioengineering Department, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, RussiaBioengineering Department, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, RussiaBioengineering Department, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, RussiaBioengineering Department, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, RussiaAnti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity. These factors significantly limit clinical applications. Due to their high specificity and affinity, tumor-specific monoclonal antibodies or their antigen-binding fragments are capable of delivering fused cytokines to tumors and, therefore, of decreasing the number and severity of side effects, as well as of enhancing the therapeutic index. The present review surveys the actual antibody–cytokine fusion protein (immunocytokine) formats, their targets, mechanisms of action, and anti-tumor and other biological effects. Special attention is paid to the formats designed to prevent the off-target cytokine–receptor interactions, potentially inducing side effects. Here, we describe preclinical and clinical data and the efficacy of the antibody-mediated cytokine delivery approach, either as a single therapy or in combination with other agents.https://www.mdpi.com/1999-4923/15/2/336immunocytokinestargeted deliveryfusion proteinscytokinesantibodiescancer treatment |
| spellingShingle | Vladislav S. Rybchenko Teimur K. Aliev Anna A. Panina Mikhail P. Kirpichnikov Dmitry A. Dolgikh Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects Pharmaceutics immunocytokines targeted delivery fusion proteins cytokines antibodies cancer treatment |
| title | Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects |
| title_full | Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects |
| title_fullStr | Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects |
| title_full_unstemmed | Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects |
| title_short | Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects |
| title_sort | targeted cytokine delivery for cancer treatment engineering and biological effects |
| topic | immunocytokines targeted delivery fusion proteins cytokines antibodies cancer treatment |
| url | https://www.mdpi.com/1999-4923/15/2/336 |
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