Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT
Background: Clomiphene citrate (CC) is the first line agent used for ovulation induction in patients with polycystic ovarian syndrome (PCOS). However, there is marked discrepancy between the ovulation and pregnancy rates achieved, which may be attributed to the undesirable effect of CC on cervical m...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Science, Yazd, Iran
2016-01-01
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| Series: | Iranian Journal of Reproductive Medicine |
| Online Access: | http://ssu.ac.ir/ijrm/index.php/ijrm/article/view/1798/930 |
| _version_ | 1818521885329063936 |
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| author | Ahmad Mahran Ayman Abdelmeged Hossam Shawki Abdelrazek Moheyelden Asmaa Mohamed Ahmed |
| author_facet | Ahmad Mahran Ayman Abdelmeged Hossam Shawki Abdelrazek Moheyelden Asmaa Mohamed Ahmed |
| author_sort | Ahmad Mahran |
| collection | DOAJ |
| description | Background: Clomiphene citrate (CC) is the first line agent used for ovulation induction in patients with polycystic ovarian syndrome (PCOS). However, there is marked discrepancy between the ovulation and pregnancy rates achieved, which may be attributed to the undesirable effect of CC on cervical mucus and endometrium. Objective: The aim of this study was to evaluate the effect of Isosorbid monoitrate (ISMN) as nitric oxide (NO) donors on the ovulation and pregnancy rates in an ovulatory women with PCOS treated with CC. Materials and Methods: Ninety patients with PCOS were randomly allocated into three groups. Patients in group A) were treated with 100 mg CC for five days starting from the fifth day of the cycle. Patients in group B) and C) received 10 mg and 20 mg of ISMN respectively in addition to CC, applied vaginally till the diagnosis of ovulation. Results: There was a significant increase in the ovulation and pregnancy rates in the patients treated with CC+ISMN as compared with patients treated with CC alone (p< 0.001). Conclusion: Concomitant use of NO with CC seems to improve the ovulation and pregnancy rates in the patients with PCOS with no significant increase in side effects as compared with CC alone. |
| first_indexed | 2024-12-11T01:57:18Z |
| format | Article |
| id | doaj.art-4434ae22a70f4d81a8240c41d5f9ac85 |
| institution | Directory Open Access Journal |
| issn | 1680-6433 2008-2177 |
| language | English |
| last_indexed | 2024-12-11T01:57:18Z |
| publishDate | 2016-01-01 |
| publisher | Shahid Sadoughi University of Medical Science, Yazd, Iran |
| record_format | Article |
| series | Iranian Journal of Reproductive Medicine |
| spelling | doaj.art-4434ae22a70f4d81a8240c41d5f9ac852022-12-22T01:24:34ZengShahid Sadoughi University of Medical Science, Yazd, IranIranian Journal of Reproductive Medicine1680-64332008-21772016-01-01141914Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCTAhmad Mahran0Ayman Abdelmeged1Hossam Shawki2Abdelrazek Moheyelden3Asmaa Mohamed Ahmed4Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia, Egypt.Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia, Egypt.Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia, EgyptDepartment of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia, Egypt.Department of Obstetrics and Gynecology, Beni-Mazar General hospital, Minia, Egypt.Background: Clomiphene citrate (CC) is the first line agent used for ovulation induction in patients with polycystic ovarian syndrome (PCOS). However, there is marked discrepancy between the ovulation and pregnancy rates achieved, which may be attributed to the undesirable effect of CC on cervical mucus and endometrium. Objective: The aim of this study was to evaluate the effect of Isosorbid monoitrate (ISMN) as nitric oxide (NO) donors on the ovulation and pregnancy rates in an ovulatory women with PCOS treated with CC. Materials and Methods: Ninety patients with PCOS were randomly allocated into three groups. Patients in group A) were treated with 100 mg CC for five days starting from the fifth day of the cycle. Patients in group B) and C) received 10 mg and 20 mg of ISMN respectively in addition to CC, applied vaginally till the diagnosis of ovulation. Results: There was a significant increase in the ovulation and pregnancy rates in the patients treated with CC+ISMN as compared with patients treated with CC alone (p< 0.001). Conclusion: Concomitant use of NO with CC seems to improve the ovulation and pregnancy rates in the patients with PCOS with no significant increase in side effects as compared with CC alone.http://ssu.ac.ir/ijrm/index.php/ijrm/article/view/1798/930 |
| spellingShingle | Ahmad Mahran Ayman Abdelmeged Hossam Shawki Abdelrazek Moheyelden Asmaa Mohamed Ahmed Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT Iranian Journal of Reproductive Medicine |
| title | Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT |
| title_full | Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT |
| title_fullStr | Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT |
| title_full_unstemmed | Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT |
| title_short | Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT |
| title_sort | nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate a rct |
| url | http://ssu.ac.ir/ijrm/index.php/ijrm/article/view/1798/930 |
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