Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases
Stilbenes are characterized by a vinyl group connecting two benzene rings to form the basic parent nucleus. Hydrogen atoms on different positions of the benzene rings can be substituted with hydroQxyl groups. These unique structural features confer anti-inflammatory, antibacterial, antiviral, antiox...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1326682/full |
| _version_ | 1797394670624440320 |
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| author | Jing Tian Li Jin Hongquan Liu Zichun Hua Zichun Hua Zichun Hua |
| author_facet | Jing Tian Li Jin Hongquan Liu Zichun Hua Zichun Hua Zichun Hua |
| author_sort | Jing Tian |
| collection | DOAJ |
| description | Stilbenes are characterized by a vinyl group connecting two benzene rings to form the basic parent nucleus. Hydrogen atoms on different positions of the benzene rings can be substituted with hydroQxyl groups. These unique structural features confer anti-inflammatory, antibacterial, antiviral, antioxidant, anticancer, cardiovascular protective, and neuroprotective pharmacological effects upon these compounds. Numerous small molecule compounds have demonstrated these pharmacological activities in recent years, including Resveratrol, and Pterostilbene, etc. Tamoxifen and Raloxifene are FDA-approved commonly prescribed synthetic stilbene derivatives. The emphasis is on the potential of these small molecules and their structural derivatives as epigenetic regulators in various diseases. Stilbenes have been shown to modulate epigenetic marks, such as DNA methylation and histone modification, which can alter gene expression patterns and contribute to disease development. This review will discuss the mechanisms by which stilbenes regulate epigenetic marks in various diseases, as well as clinical trials, with a focus on the potential of small molecule and their derivatives such as Resveratrol, Pterostilbene, and Tamoxifen. |
| first_indexed | 2024-03-09T00:23:09Z |
| format | Article |
| id | doaj.art-44366fcce0694fb18fad26c1bc6997df |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T00:23:09Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-44366fcce0694fb18fad26c1bc6997df2023-12-12T05:20:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.13266821326682Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseasesJing Tian0Li Jin1Hongquan Liu2Zichun Hua3Zichun Hua4Zichun Hua5The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, ChinaJiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, ChinaChangzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc., Changzhou, ChinaNanjing Generecom Biotechnology Co., Ltd., Nanjing, ChinaStilbenes are characterized by a vinyl group connecting two benzene rings to form the basic parent nucleus. Hydrogen atoms on different positions of the benzene rings can be substituted with hydroQxyl groups. These unique structural features confer anti-inflammatory, antibacterial, antiviral, antioxidant, anticancer, cardiovascular protective, and neuroprotective pharmacological effects upon these compounds. Numerous small molecule compounds have demonstrated these pharmacological activities in recent years, including Resveratrol, and Pterostilbene, etc. Tamoxifen and Raloxifene are FDA-approved commonly prescribed synthetic stilbene derivatives. The emphasis is on the potential of these small molecules and their structural derivatives as epigenetic regulators in various diseases. Stilbenes have been shown to modulate epigenetic marks, such as DNA methylation and histone modification, which can alter gene expression patterns and contribute to disease development. This review will discuss the mechanisms by which stilbenes regulate epigenetic marks in various diseases, as well as clinical trials, with a focus on the potential of small molecule and their derivatives such as Resveratrol, Pterostilbene, and Tamoxifen.https://www.frontiersin.org/articles/10.3389/fphar.2023.1326682/fullstilbenesepigeneticResveratrolPterostilbeneTamoxifenpositive and negative regulation |
| spellingShingle | Jing Tian Li Jin Hongquan Liu Zichun Hua Zichun Hua Zichun Hua Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases Frontiers in Pharmacology stilbenes epigenetic Resveratrol Pterostilbene Tamoxifen positive and negative regulation |
| title | Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases |
| title_full | Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases |
| title_fullStr | Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases |
| title_full_unstemmed | Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases |
| title_short | Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases |
| title_sort | stilbenes a promising small molecule modulator for epigenetic regulation in human diseases |
| topic | stilbenes epigenetic Resveratrol Pterostilbene Tamoxifen positive and negative regulation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1326682/full |
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