Enteric Neuromics: How High-Throughput “Omics” Deepens Our Understanding of Enteric Nervous System Genetic ArchitectureSummary
Recent accessibility to specialized high-throughput “omics” technologies including single cell RNA sequencing allows researchers to capture cell type- and subtype-specific expression signatures. These omics methods are used in the enteric nervous system (ENS) to identify potential subtypes of enteri...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X22002338 |
| _version_ | 1828058040405852160 |
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| author | Christine Dharshika Brian D. Gulbransen |
| author_facet | Christine Dharshika Brian D. Gulbransen |
| author_sort | Christine Dharshika |
| collection | DOAJ |
| description | Recent accessibility to specialized high-throughput “omics” technologies including single cell RNA sequencing allows researchers to capture cell type- and subtype-specific expression signatures. These omics methods are used in the enteric nervous system (ENS) to identify potential subtypes of enteric neurons and glia. ENS omics data support the known gene and/or protein expression of functional neuronal and glial cell subtypes and suggest expression patterns of novel subtypes. Gene and protein expression patterns can be further used to infer cellular function and implications in human disease. In this review we discuss how high-throughput “omics” data add additional depth to the understanding of established functional subtypes of ENS cells and raise new questions by suggesting novel ENS cell subtypes with unique gene and protein expression patterns. Then we investigate the changes in these expression patterns during pathology observed by omics research. Although current ENS omics studies provide a plethora of novel data and therefore answers, they equally create new questions and routes for future study. |
| first_indexed | 2024-04-10T21:21:34Z |
| format | Article |
| id | doaj.art-443a6a3d96ff458e915a1350f48435cb |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-04-10T21:21:34Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-443a6a3d96ff458e915a1350f48435cb2023-01-20T04:24:55ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2023-01-01152487504Enteric Neuromics: How High-Throughput “Omics” Deepens Our Understanding of Enteric Nervous System Genetic ArchitectureSummaryChristine Dharshika0Brian D. Gulbransen1Department of Physiology, Neuroscience Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, MichiganDepartment of Physiology, Neuroscience Program, Michigan State University, East Lansing, Michigan; Correspondence Address correspondence to: Brian Gulbransen, PhD, Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, Michigan 48824.Recent accessibility to specialized high-throughput “omics” technologies including single cell RNA sequencing allows researchers to capture cell type- and subtype-specific expression signatures. These omics methods are used in the enteric nervous system (ENS) to identify potential subtypes of enteric neurons and glia. ENS omics data support the known gene and/or protein expression of functional neuronal and glial cell subtypes and suggest expression patterns of novel subtypes. Gene and protein expression patterns can be further used to infer cellular function and implications in human disease. In this review we discuss how high-throughput “omics” data add additional depth to the understanding of established functional subtypes of ENS cells and raise new questions by suggesting novel ENS cell subtypes with unique gene and protein expression patterns. Then we investigate the changes in these expression patterns during pathology observed by omics research. Although current ENS omics studies provide a plethora of novel data and therefore answers, they equally create new questions and routes for future study.http://www.sciencedirect.com/science/article/pii/S2352345X22002338Computational BiologySingle Cell RNA-SequencingEnteric NeuronsEnteric Glia |
| spellingShingle | Christine Dharshika Brian D. Gulbransen Enteric Neuromics: How High-Throughput “Omics” Deepens Our Understanding of Enteric Nervous System Genetic ArchitectureSummary Cellular and Molecular Gastroenterology and Hepatology Computational Biology Single Cell RNA-Sequencing Enteric Neurons Enteric Glia |
| title | Enteric Neuromics: How High-Throughput “Omics” Deepens Our Understanding of Enteric Nervous System Genetic ArchitectureSummary |
| title_full | Enteric Neuromics: How High-Throughput “Omics” Deepens Our Understanding of Enteric Nervous System Genetic ArchitectureSummary |
| title_fullStr | Enteric Neuromics: How High-Throughput “Omics” Deepens Our Understanding of Enteric Nervous System Genetic ArchitectureSummary |
| title_full_unstemmed | Enteric Neuromics: How High-Throughput “Omics” Deepens Our Understanding of Enteric Nervous System Genetic ArchitectureSummary |
| title_short | Enteric Neuromics: How High-Throughput “Omics” Deepens Our Understanding of Enteric Nervous System Genetic ArchitectureSummary |
| title_sort | enteric neuromics how high throughput omics deepens our understanding of enteric nervous system genetic architecturesummary |
| topic | Computational Biology Single Cell RNA-Sequencing Enteric Neurons Enteric Glia |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X22002338 |
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