Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection
Background: Recent research on the implications of gut microbiota on brain functions has helped to gather important information on the relationship between them. Pathogenesis of neurological disorders is found to be associated with dysregulation of gut-brain axis. Some gut bacteria metabolites are f...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123221001867 |
| _version_ | 1829107115614011392 |
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| author | Shruti Shandilya Sandeep Kumar Niraj Kumar Jha Kavindra Kumar Kesari Janne Ruokolainen |
| author_facet | Shruti Shandilya Sandeep Kumar Niraj Kumar Jha Kavindra Kumar Kesari Janne Ruokolainen |
| author_sort | Shruti Shandilya |
| collection | DOAJ |
| description | Background: Recent research on the implications of gut microbiota on brain functions has helped to gather important information on the relationship between them. Pathogenesis of neurological disorders is found to be associated with dysregulation of gut-brain axis. Some gut bacteria metabolites are found to be directly associated with the increase in reactive oxygen species levels, one of the most important risk factors of neurodegeneration. Besides their morbid association, gut bacteria metabolites are also found to play a significant role in reducing the onset of these life-threatening brain disorders. Aim of Review: Studies done in the recent past raises two most important link between gut microbiota and the brain: “gut microbiota-oxidative stress-neurodegeneration” and gut microbiota-antioxidant-neuroprotection. This review aims to gives a deep insight to our readers, of the collective studies done, focusing on the gut microbiota mediated oxidative stress involved in neurodegeneration along with a focus on those studies showing the involvement of gut microbiota and their metabolites in neuroprotection. Key Scientific Concepts of Review: This review is focused on three main key concepts. Firstly, the mounting evidences from clinical and preclinical arenas shows the influence of gut microbiota mediated oxidative stress resulting in dysfunctional neurological processes. Therefore, we describe the potential role of gut microbiota influencing the vulnerability of brain to oxidative stress, and a budding causative in Alzheimer's and Parkinson’s disease. Secondly, contributing roles of gut microbiota has been observed in attenuating oxidative stress and inflammation via its own metabolites or by producing secondary metabolites and, also modulation in gut microbiota population with antioxidative and anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput in silico tools and databases also gives a correlation of gut microbiome, their metabolites and brain health, thus providing fascinating perspective and promising new avenues for therapeutic options. |
| first_indexed | 2024-12-12T06:32:59Z |
| format | Article |
| id | doaj.art-443ab822519f44c89d5c35ae6f905307 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-12-12T06:32:59Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-443ab822519f44c89d5c35ae6f9053072022-12-22T00:34:32ZengElsevierJournal of Advanced Research2090-12322022-05-0138223244Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotectionShruti Shandilya0Sandeep Kumar1Niraj Kumar Jha2Kavindra Kumar Kesari3Janne Ruokolainen4Department of Applied Physics, School of Science, Aalto University, Espoo, FinlandDepartment of Biochemistry, International Institute of Veterinary Education and Research, Haryana, India; Clinical Science, Targovax Oy, Saukonpaadenranta 2, Helsinki 00180, FinlandDepartment of Biotechnology, School of Engineering and Technology (SET), Sharda University, Plot no. 32–34, Knowledge Park III, Greater Noida 201310, IndiaDepartment of Applied Physics, School of Science, Aalto University, Espoo, Finland; Corresponding authors at: Department of Applied Physics Aalto University, Espoo 00076, Finland (Janne Ruokolainen). Department of Applied Physics Aalto University, Espoo 00076, Finland (Kavindra Kumar Kesari).Department of Applied Physics, School of Science, Aalto University, Espoo, Finland; Corresponding authors at: Department of Applied Physics Aalto University, Espoo 00076, Finland (Janne Ruokolainen). Department of Applied Physics Aalto University, Espoo 00076, Finland (Kavindra Kumar Kesari).Background: Recent research on the implications of gut microbiota on brain functions has helped to gather important information on the relationship between them. Pathogenesis of neurological disorders is found to be associated with dysregulation of gut-brain axis. Some gut bacteria metabolites are found to be directly associated with the increase in reactive oxygen species levels, one of the most important risk factors of neurodegeneration. Besides their morbid association, gut bacteria metabolites are also found to play a significant role in reducing the onset of these life-threatening brain disorders. Aim of Review: Studies done in the recent past raises two most important link between gut microbiota and the brain: “gut microbiota-oxidative stress-neurodegeneration” and gut microbiota-antioxidant-neuroprotection. This review aims to gives a deep insight to our readers, of the collective studies done, focusing on the gut microbiota mediated oxidative stress involved in neurodegeneration along with a focus on those studies showing the involvement of gut microbiota and their metabolites in neuroprotection. Key Scientific Concepts of Review: This review is focused on three main key concepts. Firstly, the mounting evidences from clinical and preclinical arenas shows the influence of gut microbiota mediated oxidative stress resulting in dysfunctional neurological processes. Therefore, we describe the potential role of gut microbiota influencing the vulnerability of brain to oxidative stress, and a budding causative in Alzheimer's and Parkinson’s disease. Secondly, contributing roles of gut microbiota has been observed in attenuating oxidative stress and inflammation via its own metabolites or by producing secondary metabolites and, also modulation in gut microbiota population with antioxidative and anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput in silico tools and databases also gives a correlation of gut microbiome, their metabolites and brain health, thus providing fascinating perspective and promising new avenues for therapeutic options.http://www.sciencedirect.com/science/article/pii/S2090123221001867Gut-microbiotaOxidative stressNeurodegenerationAlzheimer’s diseaseParkinson's diseaseNeurotherapeutics |
| spellingShingle | Shruti Shandilya Sandeep Kumar Niraj Kumar Jha Kavindra Kumar Kesari Janne Ruokolainen Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection Journal of Advanced Research Gut-microbiota Oxidative stress Neurodegeneration Alzheimer’s disease Parkinson's disease Neurotherapeutics |
| title | Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection |
| title_full | Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection |
| title_fullStr | Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection |
| title_full_unstemmed | Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection |
| title_short | Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection |
| title_sort | interplay of gut microbiota and oxidative stress perspective on neurodegeneration and neuroprotection |
| topic | Gut-microbiota Oxidative stress Neurodegeneration Alzheimer’s disease Parkinson's disease Neurotherapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S2090123221001867 |
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