Histone methyltransferase KMT2D cooperates with MEF2A to promote the stem-like properties of oral squamous cell carcinoma

Histone methyltransferase KMT2D cooperates with MEF2A to promote the stem-like properties of oral squamous cell carcinoma

Abstract Background Epigenetic reprogramming is involved in multiple steps of human cancer evolution and is mediated by a variety of chromatin-modifying enzymes. Specifically, the histone lysine methyltransferase KMT2D is among the most frequently mutated genes in oral squamous cell carcinoma (OSCC)...

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Bibliographic Details
Main Authors: Xinmiao Wang, Rui Li, Luping Wu, Yang Chen, Shaopeng Liu, Hui Zhao, Yifan Wang, Lin Wang, Zhe Shao
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cell & Bioscience
Subjects:
KMT2D
MEF2A
Stemness
OSCC
CTNNB1
Organoid
Online Access:https://doi.org/10.1186/s13578-022-00785-8

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