Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses

Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses

ABSTRACT Arthropod-borne viruses are diverse pathogens and are often associated with human disease. These viruses span multiple genera, including flaviviruses, alphaviruses, and bunyaviruses. In a high-throughput drug screen, we found that tenovin-1 was antiviral against the flaviviruses Zika virus...

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Bibliographic Details
Main Authors: Brent A. Hackett, Mark Dittmar, Elisha Segrist, Nathan Pittenger, Julie To, Trevor Griesman, Beth Gordesky-Gold, David C. Schultz, Sara Cherry
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
alphavirus
arbovirus
bunyavirus
flavivirus
sirtinol
sirtuin
Online Access:https://journals.asm.org/doi/10.1128/mBio.01446-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01446-19

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