Role of prophylactic HIPEC in non-metastatic, serosa-invasive gastric cancer: a literature review
The role of prophylactic hyperthermic intraperitoneal chemotherapy (p-HIPEC) in serosa invasive gastric cancers without gross or microscopic peritoneal disease, to reduce the rate of peritoneal relapse is an area of ongoing research. Although p-HIPEC is effective in reducing the rate of peritoneal r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-07-01
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| Series: | Pleura and Peritoneum |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pp-2022-0104 |
| _version_ | 1828169203689979904 |
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| author | Kunte Aditya R. Parray Aamir M. Bhandare Manish S. Solanki Sohan Lal |
| author_facet | Kunte Aditya R. Parray Aamir M. Bhandare Manish S. Solanki Sohan Lal |
| author_sort | Kunte Aditya R. |
| collection | DOAJ |
| description | The role of prophylactic hyperthermic intraperitoneal chemotherapy (p-HIPEC) in serosa invasive gastric cancers without gross or microscopic peritoneal disease, to reduce the rate of peritoneal relapse is an area of ongoing research. Although p-HIPEC is effective in reducing the rate of peritoneal relapse and improving disease free and overall survival with or without adjuvant chemotherapy, when added to curative surgery in locally advanced, non-metastatic gastric cancers, the available literature is at best, heterogeneous, centre-specific and skewed. Apart from that, variations in the systemic therapy used, and the presence of the associated nodal disease further complicate this picture. To evaluate the role of p-HIPEC the PubMed, Cochrane central register of clinical trials, and the American Society of Clinical Oncology (ASCO) meeting library were searched with the search terms, “gastric”, “cancer”, “hyperthermic”, “intraperitoneal”, “chemotherapy”, prophylactic”, “HIPEC” in various combinations, and a critical review of the available evidence was done. Although p-HIPEC is a promising therapy in the management of locally advanced gastric cancers, the current evidence is insufficient to recommend its inclusion into routine clinical practice. Future research should be directed towards identification of the appropriate patient subset and towards redefining its role with current peri-operative systemic therapies. |
| first_indexed | 2024-04-12T02:47:21Z |
| format | Article |
| id | doaj.art-4440f5579ee246f9863c9d7a4646025b |
| institution | Directory Open Access Journal |
| issn | 2364-768X |
| language | English |
| last_indexed | 2024-04-12T02:47:21Z |
| publishDate | 2022-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pleura and Peritoneum |
| spelling | doaj.art-4440f5579ee246f9863c9d7a4646025b2022-12-22T03:51:06ZengDe GruyterPleura and Peritoneum2364-768X2022-07-017310311510.1515/pp-2022-0104Role of prophylactic HIPEC in non-metastatic, serosa-invasive gastric cancer: a literature reviewKunte Aditya R.0Parray Aamir M.1Bhandare Manish S.2Solanki Sohan Lal3Department of Surgical Oncology, GI & HPB Surgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, IndiaDepartment of Surgical Oncology, GI & HPB Surgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, IndiaDepartment of Surgical Oncology, GI & HPB Surgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, IndiaDepartment of Anaesthesiology, Critical Care & Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, IndiaThe role of prophylactic hyperthermic intraperitoneal chemotherapy (p-HIPEC) in serosa invasive gastric cancers without gross or microscopic peritoneal disease, to reduce the rate of peritoneal relapse is an area of ongoing research. Although p-HIPEC is effective in reducing the rate of peritoneal relapse and improving disease free and overall survival with or without adjuvant chemotherapy, when added to curative surgery in locally advanced, non-metastatic gastric cancers, the available literature is at best, heterogeneous, centre-specific and skewed. Apart from that, variations in the systemic therapy used, and the presence of the associated nodal disease further complicate this picture. To evaluate the role of p-HIPEC the PubMed, Cochrane central register of clinical trials, and the American Society of Clinical Oncology (ASCO) meeting library were searched with the search terms, “gastric”, “cancer”, “hyperthermic”, “intraperitoneal”, “chemotherapy”, prophylactic”, “HIPEC” in various combinations, and a critical review of the available evidence was done. Although p-HIPEC is a promising therapy in the management of locally advanced gastric cancers, the current evidence is insufficient to recommend its inclusion into routine clinical practice. Future research should be directed towards identification of the appropriate patient subset and towards redefining its role with current peri-operative systemic therapies.https://doi.org/10.1515/pp-2022-0104hyperthermic intraperitoneal chemotherapyperitoneal carcinomatosisrecurrencestomach cancer |
| spellingShingle | Kunte Aditya R. Parray Aamir M. Bhandare Manish S. Solanki Sohan Lal Role of prophylactic HIPEC in non-metastatic, serosa-invasive gastric cancer: a literature review Pleura and Peritoneum hyperthermic intraperitoneal chemotherapy peritoneal carcinomatosis recurrence stomach cancer |
| title | Role of prophylactic HIPEC in non-metastatic, serosa-invasive gastric cancer: a literature review |
| title_full | Role of prophylactic HIPEC in non-metastatic, serosa-invasive gastric cancer: a literature review |
| title_fullStr | Role of prophylactic HIPEC in non-metastatic, serosa-invasive gastric cancer: a literature review |
| title_full_unstemmed | Role of prophylactic HIPEC in non-metastatic, serosa-invasive gastric cancer: a literature review |
| title_short | Role of prophylactic HIPEC in non-metastatic, serosa-invasive gastric cancer: a literature review |
| title_sort | role of prophylactic hipec in non metastatic serosa invasive gastric cancer a literature review |
| topic | hyperthermic intraperitoneal chemotherapy peritoneal carcinomatosis recurrence stomach cancer |
| url | https://doi.org/10.1515/pp-2022-0104 |
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