The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils?
Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available pharmacological treatments, indicating the need for research...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/11/3595 |
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| author | Fábio Rodrigues de Oliveira Nágila Monteiro da Silva Moisés Hamoy Maria Elena Crespo-López Irlon Maciel Ferreira Edilene Oliveira da Silva Barbarella de Matos Macchi José Luiz Martins do Nascimento |
| author_facet | Fábio Rodrigues de Oliveira Nágila Monteiro da Silva Moisés Hamoy Maria Elena Crespo-López Irlon Maciel Ferreira Edilene Oliveira da Silva Barbarella de Matos Macchi José Luiz Martins do Nascimento |
| author_sort | Fábio Rodrigues de Oliveira |
| collection | DOAJ |
| description | Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available pharmacological treatments, indicating the need for research into new anticonvulsant drugs (ACDs). The GABAergic system is the main inhibitory system of the brain and has a central role in seizures and the screening of new ACD candidates. It has been demonstrated that the action of agents on endocannabinoid receptors modulates the balance between excitatory and inhibitory neurotransmitters; however, studies on the anticonvulsant properties of endocannabinoids from plant oils are relatively scarce. The Amazon region is an important source of plant oils that can be used for the synthesis of new fatty acid amides, which are compounds analogous to endocannabinoids. The synthesis of such compounds represents an important approach for the development of new anticonvulsant therapies. |
| first_indexed | 2024-03-10T01:02:25Z |
| format | Article |
| id | doaj.art-444364fa215343f19b765acc31698ed3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T01:02:25Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-444364fa215343f19b765acc31698ed32023-11-23T14:31:32ZengMDPI AGMolecules1420-30492022-06-012711359510.3390/molecules27113595The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils?Fábio Rodrigues de Oliveira0Nágila Monteiro da Silva1Moisés Hamoy2Maria Elena Crespo-López3Irlon Maciel Ferreira4Edilene Oliveira da Silva5Barbarella de Matos Macchi6José Luiz Martins do Nascimento7Programa de Pós-Graduação em Neurociências e Biologia Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, BrazilPrograma de Pós-Graduação em Neurociências e Biologia Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, BrazilLaboratório de Farmacologia e Toxicologia de Produtos Naturais, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, BrazilPrograma de Pós-Graduação em Farmacologia e Bioquímica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá 68902-280, BrazilPrograma de Pós-Graduação em Neurociências e Biologia Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, BrazilLaboratório de Neuroquímica Molecular e Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, BrazilPrograma de Pós-Graduação em Neurociências e Biologia Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, BrazilSeizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available pharmacological treatments, indicating the need for research into new anticonvulsant drugs (ACDs). The GABAergic system is the main inhibitory system of the brain and has a central role in seizures and the screening of new ACD candidates. It has been demonstrated that the action of agents on endocannabinoid receptors modulates the balance between excitatory and inhibitory neurotransmitters; however, studies on the anticonvulsant properties of endocannabinoids from plant oils are relatively scarce. The Amazon region is an important source of plant oils that can be used for the synthesis of new fatty acid amides, which are compounds analogous to endocannabinoids. The synthesis of such compounds represents an important approach for the development of new anticonvulsant therapies.https://www.mdpi.com/1420-3049/27/11/3595GABAergic systemseizuresepilepsyplant oilsendocannabinoids |
| spellingShingle | Fábio Rodrigues de Oliveira Nágila Monteiro da Silva Moisés Hamoy Maria Elena Crespo-López Irlon Maciel Ferreira Edilene Oliveira da Silva Barbarella de Matos Macchi José Luiz Martins do Nascimento The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils? Molecules GABAergic system seizures epilepsy plant oils endocannabinoids |
| title | The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils? |
| title_full | The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils? |
| title_fullStr | The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils? |
| title_full_unstemmed | The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils? |
| title_short | The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils? |
| title_sort | gabaergic system and endocannabinoids in epilepsy and seizures what can we expect from plant oils |
| topic | GABAergic system seizures epilepsy plant oils endocannabinoids |
| url | https://www.mdpi.com/1420-3049/27/11/3595 |
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