The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance
Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3′ untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metab...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1338209 |
| _version_ | 1797677204446904320 |
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| author | Nadine Royla Stefan Kempa |
| author_facet | Nadine Royla Stefan Kempa |
| author_sort | Nadine Royla |
| collection | DOAJ |
| description | Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3′ untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism. |
| first_indexed | 2024-03-11T22:41:41Z |
| format | Article |
| id | doaj.art-4443e2710bf34012aea8011ebfc1e76d |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:41Z |
| publishDate | 2017-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-4443e2710bf34012aea8011ebfc1e76d2023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-07-014410.1080/23723556.2017.13382091338209The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistanceNadine Royla0Stefan Kempa1Berlin Institute for Medical Systems Biology at the Max Delbrueck Center for Molecular MedicineBerlin Institute for Medical Systems Biology at the Max Delbrueck Center for Molecular MedicineOur recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3′ untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.http://dx.doi.org/10.1080/23723556.2017.1338209drug resistancecancer metabolismglutaminepost-transcriptional regulation |
| spellingShingle | Nadine Royla Stefan Kempa The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance Molecular & Cellular Oncology drug resistance cancer metabolism glutamine post-transcriptional regulation |
| title | The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance |
| title_full | The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance |
| title_fullStr | The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance |
| title_full_unstemmed | The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance |
| title_short | The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance |
| title_sort | answer s in the tail myc mrna has a metabolic sensor that supports cancer chemoresistance |
| topic | drug resistance cancer metabolism glutamine post-transcriptional regulation |
| url | http://dx.doi.org/10.1080/23723556.2017.1338209 |
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