Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses

Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses

Summary Comprehensive analysis of cis-regulatory elements is key to understanding the dynamic gene regulatory networks that control embryonic development. While transgenic animals represent the gold standard assay, their generation is costly, entails significant animal usage, and in utero developmen...

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Bibliographic Details
Main Authors: Adam C. Wilkinson, Debbie K. Goode, Yi-Han Cheng, Diane E. Dickel, Sam Foster, Tim Sendall, Marloes R. Tijssen, Maria-Jose Sanchez, Len A. Pennacchio, Aileen M. Kirkpatrick, Berthold Göttgens
Format: Article
Language:English
Published: The Company of Biologists 2013-10-01
Series:Biology Open
Subjects:
ES cells
Enhancer
Haematopoiesis
Transcription
Online Access:http://bio.biologists.org/content/2/11/1229

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